| 李旭光,高 强,樊 莉,魏子湘,刘 艳.食用油与肝纤维化关系的研究进展[J].,2017,17(35):6988-6991 |
| 食用油与肝纤维化关系的研究进展 |
| The Research Advances on the Relationship between Edible Oil and Liver Fibrosis |
| 投稿时间：2016-12-24 修订日期：2017-01-19 |
| DOI：10.13241/j.cnki.pmb.2017.35.044 |
| 中文关键词: 食用油 肝纤维化 肝星状细胞 逆转 防治 |
| 英文关键词: Edible oil Liver fibrosis Hepatic stellate cells Reversion Prevention |
| 基金项目:国家自然科学基金面上项目（81421063）；哈尔滨医科大学" 创新研究小组" 基金资助 |
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| 中文摘要: |
| 摘要：慢性肝脏疾病己经成为人类健康的主要威胁，肝纤维化作为其发生发展的必经阶段，对其研究也越来越广泛和深入。随着人们生活水平的提高，饮食方式的不断改变，肝纤维化的发病率有逐年上升的趋势。但目前现有的治疗药物还无法确切有效的控制肝纤维化的发展。近年来，有研究报道，与玉米油相比，橄榄油具有良好的肝保护作用，可以缓解四氯化碳引起的小鼠肝纤维化，这种肝保护作用可能是通过橄榄油中含有较多的油酸及酚类化合物实现的。可见，不同种类的油因其所含成份的不同，对同一种疾病产生截然相反的药理作用。因此，探索和研究膳食脂质与纤维化疾病的关系，或许可以从源头上积极预防和控制肝纤维化的发生发展，不仅可以提高人们的生活质量，而且对于防治恶性肝脏疾病具有积极而深远的意义。本综述将从细胞、细胞因子以及食用油与肝纤维化的关系等方面进行探讨，从而有助于我们更加全面的理解膳食脂质在肝纤维化方面的作用。 |
| 英文摘要: |
| ABSTRACT: Chronic liver diseases have become a major threat to human health, and liver fibrosis is the necessary stage of its oc- currence and development, which is researched more deeply and widely. With the improvement of living standard and the changing of diet, the incidence of liver fibrosis is increasing year by year. However, the existing therapeutic drugs could not control the development of liver fibrosis. In recent years, studies have reported that olive oil presents benefits compared with corn oil against carbon tetrachloride-induced liver fibrosis in mice, which may be due to contain a lot of oleic acid and phenolic compounds. Different kinds of oil may have different effects on the same disease because of the different ingredients. Therefore, exploring and discovering the relationship between dietary lipids and liver fibrosis could prevent and control the occurrence and development of liver fibrosis, which can not only improve the quality of people's life, but also have a positive and far-reaching significance for the prevention and treatment of malignant liver diseases. This review will be summarized from the aspects of cells, cytokine, and edible oil related with liver fibrosis, which will help us to understand the role of dietary lipids in liver fibrosis. |
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