| 李玲艳,傅 硕,王彦臻,李亭伟,王莎莎,张 晾.人miRNA-483与疾病最新研究进展[J].,2017,17(35):6969-6971 |
| 人miRNA-483与疾病最新研究进展 |
| Recent Advances on Human miRNA-483 in Diseases |
| 投稿时间：2016-12-28 修订日期：2017-01-24 |
| DOI：10.13241/j.cnki.pmb.2017.35.039 |
| 中文关键词: microRNA miRNA-483 疾病 |
| 英文关键词: MicroRNA MiRNA-483 Disease |
| 基金项目:山东省优秀中青年科学家科研奖励基金项目（BS2013YY043）；国家级大学生创新创业训练计划项目（201510445151） |
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| 中文摘要: |
| 摘要：MicroRNA（miRNA）是一类内源基因编码的长度为22个左右核苷酸的单链非编码RNA，广泛存在于真核细胞中，通过作用于特异靶分子mRNA的3'-UTR，导致该mRNA直接降解或抑制其翻译过程，发挥转录后水平调控基因表达作用。人miR- NA-483来源于类胰岛素生长因子2 (Insulin-like growth factor 2, IGF2) 的第2内含子，经加工为miR-483-3p和miR-483-5p两个成熟体形式。近几年的研究发现人miRNA-483是一种非常重要的miRNA分子，目前已通过实验验证了10余个靶基因，通过调控靶基因参与了肿瘤发生和心血管等疾病发病过程。本文对人miRNA-483参与多种肿瘤、心血管和青光眼等多种疾病过程最新的研究进展作一综述。 |
| 英文摘要: |
| ABSTRACT: MicroRNAs（miRNAs） are a class of endogenous sigle-strand non-coding small RNAs with length about 22 nucle- otides(nt), widely exist in eukaryotic cells. By targeting specific mRNA 3'-UTR, miRNA causes the degradation or translation inhibition of target mRNA directly, which plays the role of post transcriptional regulation of gene expression. Human miRNA-483 is an important component of the family of miRNAs, which origins from 2nd intron of insulin-like growth factor 2, mainly including miR-483-3p and miR-483-5p mature moleculars. The recent studies found that miRNA-483 is closely related to tumorigenesis and cardiovascular diseases. Up to date, over 10 target genes regulated by miR-483-3p or miR-483-5p have been identified by experiments. In this paper, we review the recent progress of miRNA-483 in tumorigenesis, cardiovascular diseases, glaucoma and so on. |
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