| 樊英华,杨 岑,吴小康,张 婕,何书敏,张晓燕.健脾益气解毒方联合化疗治疗晚期结直肠癌的疗效评价[J].,2017,17(32):6315-6319 |
| 健脾益气解毒方联合化疗治疗晚期结直肠癌的疗效评价 |
| Curative Effect of Jianpi Yiqi Jiedu Decoction Combined with Chemotherapy on the Patients with Advanced Colorectal Cancer |
| 投稿时间：2017-06-06 修订日期：2017-06-26 |
| DOI：10.13241/j.cnki.pmb.2017.32.025 |
| 中文关键词: 晚期结直肠癌 健脾益气解毒汤 免疫功能 疗效 不良反应 |
| 英文关键词: Advanced colorectal cancer Jianpi Yiqi Jiedu decoction Immunity function Curative effect Adverse reactions |
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| 中文摘要: |
| 摘要 目的：探讨健脾益气解毒方联合化疗治疗晚期结直肠癌的疗效及其对患者免疫功能、生活质量的影响。方法：选择2010年6月至2015年12月在我院进行治疗的晚期结直肠癌患者80例，随机分为两组，每组40例。对照组患者接受FOLFIRI化疗，观察组患者在对照组基础上服用健脾益气解毒汤。比较两组患者治疗的临床疗效、治疗前后机体免疫功能、生活质量的变化情况及治疗期间不良反应的发生情况。结果：治疗后，观察组患者治疗的疾病控制率、CD4+以及CD4+/CD8+、KPS评分均显著高于对照组(P<0.05)，中医证侯评分及脾虚证候评分、白细胞减少、Ⅰ-Ⅱ级中性粒细胞减少以及肝损伤等不良事件的发生率均显著低于对照组(P<0.05)。结论：健脾益气解毒汤联合化疗治疗晚期结直肠癌可有效提高临床疗效，改善患者免疫功能及生活质量。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the curative effect of Jianpi Yiqi Jiedu decoction combined with chemotherapy on the patients with advanced colorectal cancer and effect on the immunity function and quality of life. Methods: 80 cases of patients with advanced colorectal cancer enrolled in our hospital from June 2010 to December 2015 were divided into two groups, the control group (n=40) was given FOLFIRI chemotherapy treatment, and the study group (n=40) adopted Jianpi yiqi jiedu decoction based on the control group. The clinical curative effect, immunity function and quality of life of patients before and after treatment, incidence of adverse reactions during treatment were compared between two groups. Results: After treatment, the disease control efficiency, content of CD4+, CD4+/CD8+, KPS score of study group were significantly higher than those of the control group (P<0.05); the TCM and spleen deficiency syndrome integral, incidence of leukocyte reduction, Ⅰ-Ⅱ neutrophil depletion and liver function damage of patients in study group were significantly lower than those of the control group (P<0.05). Conclusion: Jianpi Yiqi Jiedu decoction combined with chemotherapy not only increase the curative effect, but also improve the immunity function and quality of life for patients with advanced colorectal cancer. |
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