| 赵 聪,杨 森,罗 佳,吴於芝,孙晓娟.牙周骨再生过程中BMP-1表达变化的临床意义[J].,2017,17(31):6124-6127 |
| 牙周骨再生过程中BMP-1表达变化的临床意义 |
| Clinical Significance of BMP-1 Expression in the Periodontal Bone Regeneration |
| 投稿时间：2017-06-04 修订日期：2017-06-28 |
| DOI：10.13241/j.cnki.pmb.2017.31.029 |
| 中文关键词: 骨形态发生蛋白-1 牙周骨 缺损 骨再生 引导组织再生术 |
| 英文关键词: Bone morphogenetic protein-1 Periodontal bone Defect Bone regeneration Guided tissue regeneration |
| 基金项目:遂宁市科技计划项目（2014s47） |
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| 中文摘要: |
| 摘要 目的：观察在牙周骨再生过程中骨形态发生蛋白-1(BMP-1)的表达的变化情况及临床意义。方法：以我院收治的牙周骨缺损患者196例作为研究对象，采用常规的基础牙周治疗(龈上洁治彻底，龈下刮治，整平根面)处理后，通过引导组织再生术(GTR)技术对骨缺损进行修复的同时，植入Bio-oss 人工骨材料和Bio-gide 胶原膜。在治疗前和治疗后，分别测定患者血清BMP-1水平，分析BMP-1表达水平与牙周骨缺损修复的关系。结果：与治疗前相比，患者治疗后的牙周骨缺损均有所修复，所有患者在术后所有时间点的PPD和骨密度值与治疗前相比均显著改善(P<0.05)。治疗6个月后，牙周骨密度出现小幅度下降，但显著高于治疗前，差异具有统计学意义(P<0.05)。与治疗前相比，所有患者治疗后1 d、2 d、5 d、10 d、1个月、3个月、6个月血清BMP-1的水平均显著升高，差异具有统计学意义(P<0.05)，且治疗后BMP-1水平的变化与PPD呈显著负相关（P<0.05），但与骨密度的相关性不显著（P>0.05）。结论：血清BMP-1在牙周骨修复过程存在动态变化与患者牙周骨术后恢复相关。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the expression of serum bone morphogenetic protein-1 (BMP-1) during the process of periodon- tal bone regeneration and its clinical significance. Methods: 196 cases of patients with periodontal bone defects admitted in our hospital were enrolled in this study, conventional basic periodontal treatment (gingival Jie governance thoroughly, subgingival scaling cure, level- ing the root surface) was used. The Bio-oss artificial bone material and the Bio-gide collagen membrane were implanted while the bone defect was repaired by guided tissue regeneration (GTR). The levels of serum BMP-1 were measured before and after treatment, and the relationship between the expression of BMP-1 and the repair of periodontal bone defects was analyzed. Results: Compared with before treatment, patients with periodontal bone defects were repaired after treatment. The PPD and bone mineral density of all patients were significantly improved (P<0.05) after treatment. The bone mineral density (BMD) decreased significantly after 6 months of treatment, but it was significantly higher than that before treatment (P<0.05). Compared with before treatment, the levels of serum BMP-1 were signifi- cantly increased in all patients at 1 day, 2 days, 5 days, 10 days, 1 month, 3 months and 6 months after treatment(P<0.05), and the level of BMP-1 was negatively correlated with PPD (P<0.05), but the correlation with bone mineral density showed no significant difference(P>0.05). Conclusion: It was found that the dynamic changes of BMP-1 in periodontal bone repair were related to the recovery of periodontal bone. |
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