| 梁鹏锋,张海鹏,范 明,张 梁,王 谦.不同方式治疗原发性肝癌合并门静脉癌栓的治疗效果比较[J].,2017,17(29):5765-5768 |
| 不同方式治疗原发性肝癌合并门静脉癌栓的治疗效果比较 |
| Comparison of Different Therapeutic Methods to Treat Primary Hepatocellular Carcinoma with Portal Vein Tumor Thrombus |
| 投稿时间：2016-03-17 修订日期：2016-04-18 |
| DOI：10.13241/j.cnki.pmb.2017.29.039 |
| 中文关键词: 原发性肝癌 门静脉癌栓 化疗 手术治疗 |
| 英文关键词: Primary hepatocellular carcinoma Portal vein tumor thrombus Chemotherapy Surgery |
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| 中文摘要: |
| 摘要 目的：对不同方式治疗原发性肝癌（HCC）合并门静脉癌栓（PVTT）的治疗效果进行比较。方法：收取我院2010年2月至2013年3月收治的HCC合并PVTT患者83例进行回顾性分析，按照治疗方法的不同分为A组（手术+经导管动脉化疗栓塞TACE）26例、B组（手术+门静脉化疗PVC）25例以及C组（手术+TACE+PVC）32例。对三组患者不良反应发生情况、生存率、生存质量进行考察与比较，并对可能影响生存率的因素进行分析。结果：三组患者均行手术切除，切除率为100%。三组患者化疗后不良反应发生率方面比较差异无统计学意义（P>0.05）。C组患者生存质量提高总有效率及改善率分别为78.13 %和50.00 %，均显著高于其他两组，差异有统计学意义（P<0.05）。C组患者中位生存时间及半年、1年、2年、3年生存率均显著高于A组和B组，差异具有统计学意义（P<0.05）。影响HCC合并PVTT患者的主要因素包括肿瘤大小、肿瘤数目、病理分级及癌栓类型（P<0.05）。结论：HCC合并PVTT患者术后使用TACE+PVC联合治疗可有效提高患者生存率，改善生活质量。 |
| 英文摘要: |
| ABSTRACT Objective: To compare the curative effect of different therapeutic methods in treatment of primary hepatocellular carci- noma (HCC) with portal vein tumor thrombus (PVTT). Methods: 83 HCC with PVTT patients accepted in our hospital from February 2010 to March 2013 were retrospectively analyzed and divided into group A (surgery+ Transcatheter arterial chemoembilization, TACE) with 26 cases, group B (surgery+via Portal vein chemotherapy, PVC) with 25 cases and group C (surgery+TACE+PVC) with 32 cases ac- cording to different therapeutic methods. The adverse reactions, survival rate and life quality of three groups was observed and compared. Then the influence factors of survival rate were analyzed. Results: All patients underwent surgery. The surgery rate was 100 %. The ad- verse reactions of three groups after chemotherapy had no statistically difference (P>0.05). The total efficacy and improvement rate of life quality of group C was respectively 78.13 % and 50.00 %, which were higher than that of the other two groups (P<0.05). The median sur- vival time and half year,1-, 2- and 3-years survival rate of group C was obviously higher than that of group A and group B with statistically significance (P<0.05). The major influence factors of HCC with PVTT were tumor size, number and pathological grade (P<0.05). Conclusion: TACE combined with PVC after surgery for HCC with PVTT patients can improve survival rate and life quality. |
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