| 魏志成,刘 荣,王春喜,胡明根,赵之明.肝门部胆管癌根治术术后口服胆汁患者的疗效观察[J].,2017,17(29):5698-5700 |
| 肝门部胆管癌根治术术后口服胆汁患者的疗效观察 |
| Curative Effect Observation of Patients Drinking Bile Postoperatively of Radical Resection of Hilar Cholangiocarcinoma |
| 投稿时间：2017-05-08 修订日期：2017-05-31 |
| DOI：10.13241/j.cnki.pmb.2017.29.022 |
| 中文关键词: 胆管细胞恶性肿瘤 口服胆汁 肝门胆管癌根治术 |
| 英文关键词: Cholangiocarcinoma Bile oral administration Radical resection of hilar cholangiocarcinoma |
| 基金项目:国家自然科学基金青年基金项目（61601330） |
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| 中文摘要: |
| 摘要 目的：探讨肝门部胆管癌术后口服胆汁患者的疗效。方法：采用病例对照法，回顾性分析2015年10月-2016年9月期间我科收治的肝门部胆管癌患者，术前行经皮肝穿刺胆道引流术（PTCD）并接受肝门部胆管癌根治术的患者89例，根据术后是否口服胆汁，将肝门部胆管癌患者分为两组，即口服胆汁组（51例）及对照组（38例）。所有患者均为术后3日开始进食。口服胆汁组：胆汁口服应遵循的条件为引流出的胆汁呈金黄色、无血性。术后第三天，胆汁满足口服的条件时，每6小时收集一次，经双层纱布过滤，胆汁中加入蜂蜜少量多次、随餐服下。对照组：除外口服胆汁，其余进食及治疗均相同。术后主要结局观察指标包括腹泻发生率、术后7天血清白蛋白水平，腹腔感染发生率；次要结局指标即住院时间。观察术后患者腹泻发生率、术后7天血清白蛋白水平，腹腔感染发生率和住院时间。结果：两组患者腹腔感染、腹泻发生及住院时间有统计学差异，p值均小于0.05，两组间白蛋白水平无统计学差异。结论：口服胆汁是一种有效、简便且经济的方法。术后腹腔感染并发症少，缩短住院时间，腹泻发生率较低。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the curative effect of oral administration of bile on hilar cholangiocarcinoma patients after surgery. Methods: In a case-control study, retrospective analysis of patients with hilar cholangiocarcinoma admitted in our department during October 2015 -2016 September, underwent percutaneous transhepatic biliary drainage (PTCD) and 89 patients underwent radical resection of hilar cholangiocarcinoma, according to whether the oral bile after surgery, the patients with hilar cholangiocarcinoma divided into two groups, namely oral bile group (51 cases) and control group (38 cases). All patients began eating at 3 days after surgery. Oral bile group: oral bile should follow the condition that the bile out of the drainage is golden and bloodless. Third days after the operation, to meet the conditions of oral bile, collected once every 6 hours, the double-layer gauze filtration, a few times, adding honey with meals in bile. Control group: except for oral bile, the rest of the diet and treatment are the same. The main outcome measures included the rate of diarrhea, serum albumin level, the rate of abdominal infection, and the secondary outcome measure, the length of hospital stay, 7 days after operation. The incidence of diarrhea, the serum albumin level, the rate of abdominal infection and the length of hospital stay were observed 7 days after operation. Results: There were statistical difference existing in incidence of abdominal infection and diarrhea, and hospitalization time between two groups (all P＜0.05). No significant difference was found in serum albumin levels between the two groups. Conclusion: Oral administration of bile is an effective, simple and economical method. There were fewer complications, shorter hospitalization time, and lower incidence of diarrhea. |
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