| 崔永建,王 建,李 艳,张红霞,刘 佳.塞米松棕榈酸酯、维生素B12、利多卡因关节腔内注射对膝关节骨性关节炎患者血清IL-1，MMP-3及TIMP-1水平的影响[J].,2017,17(24):4664-4667 |
| 塞米松棕榈酸酯、维生素B12、利多卡因关节腔内注射对膝关节骨性关节炎患者血清IL-1，MMP-3及TIMP-1水平的影响 |
| Curative Efficacy of Combined Use of Dexamethasone Palmitate, Vitamin B12 and Lidocaine in Treatment of Knee Osteoarthritis and Serum Levels of IL-1, MMP-3 and TIMP-1 |
| 投稿时间：2017-02-05 修订日期：2017-02-26 |
| DOI：10.13241/j.cnki.pmb.2017.24.015 |
| 中文关键词: 关节腔内注射 膝骨性关节炎 白介素-1 软骨基质金属蛋白酶-3 基质金属蛋白酶抑制剂-1 |
| 英文关键词: Intraarticular injection Knee osteoarthritis Interleukin-1 Cartilage matrix metalloproteinase-3 Matrix metalloproteinase inhibitor-1 |
| 基金项目:国家自然科学基金项目(81072830) |
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| 中文摘要: |
| 摘要 目的：研究塞米松棕榈酸酯、维生素B12、利多卡因联合使用对膝骨性关节炎的疗效及对血清白介素-1(IL-1)、软骨基质金属蛋白酶3(MMP-3)、基质金属蛋白酶抑制剂1(TIMP-1)的影响。方法：选取2014年8月至2015年7月新疆医科大学第六附属医院收治的84例膝骨性关节炎患者，根据入院顺序分为观察组和对照组，42例每组。观察组采取塞米松棕榈酸酯、维生素B12、利多卡因进行关节腔内注射，对照组采取中药涂抹方案。评判患者治疗后的临床疗效，比较两组患者治疗前和治疗1个月后血清IL-1、MMP-3、TIMP-1水平、视觉模拟(VAS)评分的变化。结果：治疗后，观察组临床总有效率显著高于对照组(P<0.05)，两组患者的血清IL-1、MMP-3、VAS评分均显著低于治疗前(P<0.05)，血清TIMP-1水平明显高于治疗前，且观察组的IL-1、MMP-3、TIMP-1、VAS评分水平显著低于对照组，血清TIMP-1水平明显高于对照组(P<0.05)。结论：采取塞米松棕榈酸酯、维生素B12、利多卡因关节腔内注射治疗膝骨性关节炎患者能有效降低患者血清IL-1、MMP-3水平，升高TIMP-1水平，缓解患者疼痛感，临床疗效良好。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the curative efficacy of combined use of dexamethasone palmitate, vitamin B12 and lidocaine in the treatment of knee osteoarthritis and its effects on the seum levels of interleukin-1(IL-1), matrix metalloproteinase-3 (MMP-3) and matrix metalloproteinase-1 (TIMP-1). Methods: 84 patients with osteoarthritis of knee were selected from August 2014 to July 2015 in Sixth Affiliated Hospital of Xinjiang Medical University and divided into the observation group and the control group according to the order of admission, 42 cases in each group. The observation group was given intra-articular injection of dexamethasone palmitate, vitamin B12 and lidocaine, and the control group was treated with traditional Chinese medicine. The clinical efficacy was evaluated after treatment. The changes of serum IL-1, MMP-3, TIMP-1 levels and visual analogue (VAS) score were compared before and at 1 months after treatment. Results: After treatment, the total effective rate of observation group was significantly higher than that of the control group(P<0.05), the serum levels of IL-1, MMP-3 levels and VAS score were significantly lower than those before treatment, serum TIMP-1 level was obviously higher than that before treatment(P <0.05), the serum levels of IL-1, MMP-3 levels were significantly lower in the observation group than those of the control group, while the serum TIMP-1 level was obviously higher than(P<0.05) Conclusion: Intra-articular injection with dexamethasone palmitate, vitamin B12 and lidocaine could effectively decrease the levels of serum IL-1 and MMP-3, increase the level of TIMP-1, and relieve the pain in the patients with knee osteoarthritis. |
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