| 侍相君,王振福,陈予东,高中宝,王 炜,王 洁.丘脑底核-深部脑刺激术术后淡漠的研究进展[J].,2017,17(23):4590-4592 |
| 丘脑底核-深部脑刺激术术后淡漠的研究进展 |
| Advances in Research on the Apathy of the Subthalamic Nucleus - deep Brain Stimulation |
| 投稿时间：2017-03-05 修订日期：2017-03-30 |
| DOI：10.13241/j.cnki.pmb.2017.23.046 |
| 中文关键词: 帕金森病 丘脑底核-深部脑刺激术 淡漠 |
| 英文关键词: Parkinson's disease STN-DBS apathy |
| 基金项目:国家重点研究发展计划项目(2016YFC1306600)；北京市科技计划项目(Z151100004015206) |
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| 中文摘要: |
| 摘要：帕金森病(Parkinson's disease，PD)是一种由于中脑黑质以及其他核团结构的多巴胺能神经元变性所致的以进行性运动功能障碍为主要表现的疾病。近年来，双侧高频刺激的丘脑底核-深部脑刺激术（STN-DBS）治疗PD效果确切，疗效较好，但其出现了术后淡漠等类似副作用，严重影响了PD治疗效果和患者的生活质量，引起了临床医生的高度重视。本文对STN-DBS术后淡漠发病情况、表现及治疗进行综述，为临床诊治提供思路。 |
| 英文摘要: |
| ABSTRACT: Parkinson's disease is characterized by progressive motor dysfunction owing to degeneration of dopaminergic neurons in the substantia nigra and other nuclei. Recently, the bilateral high frequency stimulation of the subthalamic nucleus deep brain stimula- tion(STN-DBS) as the treatment of PD was famous with good curative effect. But postoperative apathy as its side-effect impact on the therapeutic effect and the quality of life of patients seriously, which drawn the attention of clinicians. In this article, we summarized the incidence, manifestation and treatment of postoperative apathy and tried to provide some ideas for clinicians. |
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