| 陈 莹,魏国庆,夏洪伟,毕 锋,刘 明.肿瘤中高表达的长链非编码RNA HOTTIP提示较差预后：六项研究的结果汇总[J].,2017,17(22):4376-4381 |
| 肿瘤中高表达的长链非编码RNA HOTTIP提示较差预后：六项研究的结果汇总 |
| High Expression of Long Non-coding RNA HOTTIP Indicates Poor Prognosis in Cancers: Evidence from Six Studies |
| 投稿时间：2017-01-11 修订日期：2017-02-28 |
| DOI：10.13241/j.cnki.pmb.2017.22.043 |
| 中文关键词: meta分析 长链非编码RNA HOTTIP 肿瘤 预后 |
| 英文关键词: Meta-analysis Long non-coding RNA HOTTIP Cancer Prognosis |
| 基金项目:国家自然科学基金项目（81572850） |
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| 中文摘要: |
| 摘要 目的：近些年来长链非编码RNA（long non-coding RNA, lncRNA）在各类肿瘤的早期诊断及预测预后中的重要作用受到越来越多的重视。然而长链非编码RNA HOXA 转录本末端RNA （HOXA transcript at the distal tip, HOTTIP）作为肿瘤发展中的重要长链非编码RNA，其在肿瘤中的预后价值仍有待研究。本研究通过分析HOTTIP表达和不同肿瘤类型的总生存期（overall survival, OS），淋巴结转移（lymph node metastasis, LNM）及远处转移（distant metastasis, DM）来评价其作为肿瘤预后指标的价值。方法：通过在PUBMED，MEDLINE，Web of Science 以及Cochrane Library 系统性查找截止于2016年11月所有相关文献，最终纳入6项研究共604例患者。通过Review Manager 5.3对这6项研究进行meta分析。结果：我们发现长链非编码RNA HOTTIP高表达的患者总生存较差（风险比 [hazard ratio, HR] =2.37, 95% 置信区间[confidence interval, CI] =1.81-3.10, p<0.001），并具有较高的淋巴结转移率（比值比[odds ratio , OR]=2.29, 95%CI=1.54-3.40, p<0.001）和较高的远处转移发生率（OR=3.30, 95%CI=1.78-6.12, p<0.001）显著相关。结论：我们的分析结果提示长链非编码RNA HOTTIP可是作为肿瘤中预测预后的重要生物标志物。 |
| 英文摘要: |
| ABSTRACT Objective: The significant role of long non-coding RNAs (lncRNAs) in early diagnosis and predicting prognosis has been recognized in various cancers recently. However, the prognostic value of HOXA transcript at the distal tip (HOTTIP), a vital lncRNA in tumorigenesis, remains unclear. In this study, we evaluated its prognostic value by analyzing the correlation of HOTTIP expression with overall survival (OS), lymph node metastasis (LNM) and distant metastasis (DM) in different cancer types by meta-analysis. Methods: We performed a systematic search in PUBMED, MEDLINE, Web of Science and Cochrane Library update to November of 2016. A total of 604 patients from 6 studies were included in final analysis and went through a quantitative meta-analysis by Review manager 5.3. Results: We demonstrated that high expression of HOTTIP had a significant correlation with poor OS (hazard ratio [HR] =2.37, 95% confidence interval [CI] =1.81-3.10, p<0.001), high LNM rate (odds ratio [OR]=2.29, 95%CI=1.54-3.40, p<0.001) as well as more DM occurrence (OR=3.30, 95%CI=1.78-6.12, p<0.001). Conclusion: Our results indicated that long non-coding RNA HOTTIP may serve as a potential prognostic biomarker in cancer progression. |
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