| 胡艳云,李鸿燕,边志颖,贾丽艳,陈 婕.α-硫辛酸对2型糖尿病血管病变患者血清CRP，IL-6，VEGF，VCAM-1水平的影响[J].,2017,17(21):4143-4146 |
| α-硫辛酸对2型糖尿病血管病变患者血清CRP，IL-6，VEGF，VCAM-1水平的影响 |
| Effect of α-lipoic Acid on Serum CRP, IL-6, VEGF and VCAM-1 Levels of Patients with Type 2 Diabetic Vascular Disease |
| 投稿时间：2017-01-12 修订日期：2017-01-30 |
| DOI：10.13241/j.cnki.pmb.2017.21.036 |
| 中文关键词: α-硫辛酸 2型糖尿病 血管病变 C反应蛋白(CRP) 白细胞介素-6(IL-6) 血管内皮生长因子(VEGF) 血管细胞黏附因子(VCAM-1) |
| 英文关键词: α-lipoic acid Type 2 diabetes Vascular lesions C reactive protein (CRP) Interleukin -6 (IL-6) Vascular endothelial growth factor (VEGF) Vascular cell adhesion factor (VCAM-1) |
| 基金项目:河北省自然科学基金项目(C2009001061) |
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| 中文摘要: |
| 摘要 目的：研究α-硫辛酸治疗2型糖尿病血管病变的临床疗效及其对血清C反应蛋白(CRP)、白细胞介素-6(IL-6)、血管内皮生长因子(VEGF)、血管细胞黏附因子(VCAM-1)水平的影响。方法：选取2015年8月至2016年7月本院收治的82例2型糖尿病血管病变患者，根据随机数字法分为观察组和对照组，41例每组。对照组使用甲钴胺治疗，观察组使用α-硫辛酸治疗。评价两组患者的临床疗效，比较两组患者治疗前后血清CRP、IL-6、VEGF、VCAM-1及血脂水平的变化。结果：治疗后，观察组总有效率显著高于对照组[92.68%(38/41)比60.98%(25/41)](P<0.05)。治疗后，两组患者血清CRP、IL-6、VEGF、VCAM-1、低密度脂蛋白胆固醇(LDL-C)、三酰甘油(TG)、总胆固醇(TC)水平较治疗前显著降低(P<0.05)，血清高密度脂蛋白胆固醇(HDL-C)水平较治疗前明显升高(P<0.05)。与对照组相比，观察组治疗后血清CRP、IL-6、VEGF、VCAM-1、LDL-C、TG、TC水平更低(P<0.05)，HDL-C水平较高(P<0.05)。结论：α-硫辛酸治疗能明显降低2型糖尿病血管病变患者血清CRP、IL-6、VEGF、VCAM-1水平，且临床疗效较好。 |
| 英文摘要: |
| ABSTRACT Objective: To study the clinical effect of α-lipoic acid on the serum levels of C-reactive protein (CRP), interleukin-6 (IL-6), vascular endothelial growth factor (VEGF) and vascular cell adhesion factor (VCAM-1) of patients with type 2 diabetes combined with vascular disease. Methods: 82 patients with type 2 diabetes mellitus who were treated in our hospital from August 2015 to July 2016 were selected and randomly divided into the observation group and the control group, with 41 patients in each group. The patients in the control group were treated with methylcobalamin, while the patients in the observation group were treated with α-lipoic acid. Then the serum levels of CRP, IL-6, VEGF, VCAM-1 and blood lipid in the two groups were observed and compared before and after the treat- ment. Results: After treatment, the total effective rate in the observation group was significantly higher than that of the control group (P <0.05). After treatment, the serum levels of CRP, IL-6, VEGF and VCAM-1 in the two groups were lower than those before treatment(P<0.05). Compared with the control group, the serum levels of CRP, IL-6, VEGF and VCAM-1 in the observation group were lower(P<0.05). After treatment, the serum levels of LDL-C, TG and TC in the two groups were significantly lower than those before treatment, while the HDL-C level was significantly higher (P<0.05). Compared with the control group, the serum levels of LDL-C, TG and TC in the observation group were lower, while the HDL-C was higher (P<0.05). Conclusion: α-lipoic acid could reduce the serum levels of CRP, IL-6, VEGF and VCAM-1 of patients with type 2 diabetes mellitus with obvious clinical curative effect. |
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