| 周海鸥,余 跃,施 燕,徐其远,张琳琳,张 涛.不同剂量乌司他丁对急性胰腺炎患者血清TNF-α，IL-1，IL-6及IL-8水平的影响[J].,2017,17(21):4096-4099 |
| 不同剂量乌司他丁对急性胰腺炎患者血清TNF-α，IL-1，IL-6及IL-8水平的影响 |
| Effects of Different Doses of Ulinastatin on Serum Levels of TNF-α, IL-1, IL-6 and IL-8 in Patients with Acute Pancreatitis |
| 投稿时间：2017-02-05 修订日期：2017-02-27 |
| DOI：10.13241/j.cnki.pmb.2017.21.024 |
| 中文关键词: 乌司他丁 急性胰腺炎 肿瘤坏死因子-α 白介素-1 白介素-6 白介素-8 |
| 英文关键词: Ulinastatin Acute pancreatitis Tumor necrosis factor-α Interleukin-1 Interleukin-6 Interleukin-8 |
| 基金项目:安徽省科技计划项目（12014402136） |
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| 中文摘要: |
| 摘要 目的：探讨不同剂量乌司他丁对急性胰腺炎患者血清TNF-α、IL-1、IL-6、IL-8含量影响。方法：收集我院消化内科收治的急性胰腺炎患者72例，随机分为试验组和对照组，各36例。对照组予以10万IU静点，每8 h 1次；试验组患者予以乌司他丁30万IU静点，每8 h 1次。治疗后比较患者临床症状、血清TNF-α、IL-1、IL-6、IL-8含量、血淀粉酶、肝脏功能以及不良反应发生情况。结果：治疗后，与治疗前相比两组AMY、ALT以及Cr水平均降低（P＜0.05），血清 TNF-α、IL-1、IL-6、IL-8水平均降低（P＜0.05）。与对照组相比，试验组治疗有效率较高（P＜0.05）；试验组临床症状消失时间、实验室指标恢复时间以及住院天数缩短（P＜0.05）；试验组TNF-α、IL-1、IL-6、IL-8水平较低（P＜0.05）；试验组AMY、ALT以及Cr水平较低（P＜0.05）。结论：大剂量乌司他丁应用于急性胰腺炎的治疗安全有效，较正常剂量相比，能够缩短治疗时间，降低TNF-?琢、IL-1、IL-6、IL-8等炎症因子水平。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of different doses of ulinastatin on the serum levels of TNF-α, IL-1, IL-6 and IL-8 in patients with acute pancreatitis. Methods: 72 patients with acute pancreatitis were selected and randomly divided into the treatment group and the control group (n=36). The patients in the control group were treated with 10 million IU static, while the patients in the treatment group were treated with 30 million IU static. Then the serum levels of serum TNF-α, IL-1, IL-6 and IL-8, the liver function and the adverse reactions in the two groups were observed and compared before and after the treatment. Results: Compared with before treat- ment, the serum levels of AMY, ALT, Cr, TNF-α, IL-1, IL-6 and IL-8 in the two groups decreased after the treatment (P<0.05); Com- pared with the control group, the effective rate of the treatment group was higher (P<0.05); The time of disappearance of clinical symp- toms, the recovery time of laboratory indexes and hospitalization in the treatment group were shorter, and the serum levels of TNF-α, IL-6, IL-8, AMY, ALT and Cr were lower (P<0.05). Conclusion: Ulinastatin was effective and safe in the treatment of acute pancreatitis. It can shorten the treatment time and lower the levels of TNF-α, IL-1, IL-6, IL-8 and other inflammatory factors compared with the nor- mal dose. |
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