| 高伟芳,李 晓,桑荣霞,李 宁,刘 铭,韩占波.急性胆源性胰腺炎患者hs-CRP及PCT的表达及意义[J].,2017,17(19):3730-3733 |
| 急性胆源性胰腺炎患者hs-CRP及PCT的表达及意义 |
| Expression and Significance of hs-CRP and PCT in Patients with Acute Biliary Pancreatitis |
| 投稿时间：2016-10-17 修订日期：2016-11-15 |
| DOI：10.13241/j.cnki.pmb.2017.19.033 |
| 中文关键词: 急性胆源性胰腺炎 超敏C反应蛋白 降钙素原 意义 |
| 英文关键词: Acute biliry pancreatitis High sensitive C reactive protein Procalcitonin Significance |
| 基金项目:石家庄市直医疗卫生计生单位第二批科学技术研究与发展指导计划课题（141463143） |
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| 中文摘要: |
| 摘要 目的：探讨血清超敏C反应蛋白（hs-CRP）和降钙素原（PCT）在急性胆源性胰腺炎（ABP）患者中的表达及意义。方法：选择本院2015年4月-2015年12月收治的56例ABP患者，根据疾病严重程度分为轻症ABP（MABP组）38例及重症ABP（SABP组）18例，根据患者预后分为存活组52例和死亡组4例，另选42例单纯胆囊结石症患者作为对照组。分别于入院第1、3、7 d检测所有患者血清中hs-CRP和PCT水平，对患者进行改良Ranson评分、急性生理及慢性健康状况评分Ⅱ（APACHEⅡ）评价，分析血清hs-CRP及PCT水平与两评分的相关性。结果：入院后三组血清hs-CRP、PCT逐渐升高，第3 d到达峰值，随后逐渐下降，但第7 d时仍较第1 d高（P<0.05），与对照组相比，MABP组、SABP组患者血清中hs-CRP、PCT水平明显升高，且SABP组患者血清hs-CRP、PCT水平显著高于MABP组（P<0.05）；存活组患者血清hs-CRP、PCT水平较死亡组明显较低（P<0.05）；患者血清hs-CRP、PCT水平改变与改良Ranson评分及APACHEⅡ评分呈正相关（P<0.05）。结论：ABP患者血清hs-CRP和PCT水平呈高表达，检测两指标可评价患者病情严重程度、预测患者预后情况。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the expression and prognostic significance of hs-CRP and PCT in patients with acute biliary pancreatitis. Methods: 56 cases of ABP patients who treated in our hospital from April 2015 to December 2015, according to the severity of the disease were divided into Mild ABP (MABP group) with 38 cases and severe ABP (SABP group) with 18 cases. According to the prognosis of the patients, they were divided into the survival group with 52 cases and death group with 4 cases. Another 42 cases with simple gallstone patients as the control group. Hs-CRP and PCT levels were detected in all patients, after admission of first, third and 7th, respectively, and the modified Ranson score, Acute Physiology and Chronic Health EvaluationⅡscore were determined. Analysed the the correlation between serum hs-CRP,CT levels and the two score. Results: After admission, Serum hs-CRP and PCT levels in three groups reached the peak at the third day,then decreased gradually, but the 7th day was still higher than the first day (P<0.05). Compared with the control group, MABP group and SABP group serum hs-CRP and PCT levels were significantly increased, and the serum hs-CRP and PCT levels in SABP group was significantly higher than that in MABP group (P<0.05). Serum hs-CRP and PCT levels of survival group were significantly lower than death group (P<0.05). The hs-CRP and PCT levels were positively correlated with Modified Ranson score and APACHE score (P<0.05). Conclusion: High expression of serum hs-CRP and PCT levels in ABP patients,the detection of two indica- tors can evaluate the severity of the patient's condition, predict the prognosis of patients. |
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