| 张洋洋,彭效祥,孙艳丽,赵荣兰.甲状腺激素受体β与肿瘤关系研究进展[J].,2017,17(18):3588-3591 |
| 甲状腺激素受体β与肿瘤关系研究进展 |
| Progress on the Relationship between Thyroid Hormone Receptor β and Tumor |
| 投稿时间：2016-10-10 修订日期：2016-11-03 |
| DOI：10.13241/j.cnki.pmb.2017.18.044 |
| 中文关键词: 甲状腺激素受体 甲状腺激素受体β 肿瘤 综述 |
| 英文关键词: Thyroid hormone receptor Thyroid hormone receptor β Tumor Review |
| 基金项目:国家自然科学基金项目（81301737）；山东省自然科学基金项目（ZR2015HL025；ZR2015HL036） |
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| 中文摘要: |
| 摘要：甲状腺激素受体（thyroid hormone receptors, TRs）是一种配体依赖性转录因子，由TRα和TRβ基因编码。在哺乳动物中已发现多个不同的TR亚型，分别由TRα和TRβ基因由于转录起始位点的不同或选择性剪接而产生的若干同工体。近年来被越来越多的研究证实TRs除参与调控机体正常的发育和代谢平衡外，还具有对肿瘤发生的调节作用，尤其是TR?茁亚型在肿瘤的发生、发展及转移等过程中发挥重要的生物学作用，表现出了明显的肿瘤抑制功能。在多种肿瘤组织中可检测到TRβ表达的降低甚至缺失。TRβ参与调控细胞内多个信号转导通路，与肿瘤的发生发展密切相关。对TRβ参与的细胞内调控机制的研究有助于在分子水平上对肿瘤的发生发展作更深入的了解，以发掘新的肿瘤治疗靶点。本文主要对TRβ与肿瘤关系的研究进展进行综述。 |
| 英文摘要: |
| ABSTRACT: Thyroid hormone receptors (TRs) coded by TRα and TRβ genes are a kind of ligand dependent transcription factor. In mammals, a number of different TR subtypes have been found, and because of different transcript start position or alternative splicing, each subtype has several isoforms. In recent years, more and more researches have confirmed that TRs have a regulating effect on tumorigenesis in addition to the regulation of normal body development and metabolic balance, especially TRβ subtype plays an important biological role in the occurrence, development and metastasis of tumor, and shows a significant tumor suppressor function. In a variety of tumor tissues, the expression of TRβ reduced or even lost. TRβ is involved in the regulation of intracellular signal transduction pathways closely relating to the occurrence and development of tumor. The studies on the mechanism of intracellular regulation of TRβ are helpful to understand the development of tumor at the molecular level, and to explore new therapeutic targets for tumor therapy. This study gives a review on the relationship between TRβ and tumor. |
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