| 王高翔,陶 蕾,李正民,牛江涛,孙绪德.右美托咪定对颅脑损伤手术患者氧化应激反应的影响[J].,2017,17(18):3470-3472 |
| 右美托咪定对颅脑损伤手术患者氧化应激反应的影响 |
| Effect of Dexmedetomidine on Oxidative Stress in Patients with Craniocerebral Trauma Operation |
| 投稿时间：2016-12-16 修订日期：2016-12-30 |
| DOI：10.13241/j.cnki.pmb.2017.18.015 |
| 中文关键词: 颅脑损伤 右美托咪定 氧化应激 脑保护 |
| 英文关键词: Craniocerebral trauma Dexmedetomidine Oxidative stress Cerebral protection |
| 基金项目:陕西省自然科学基金项目 ( 99SM39) |
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| 中文摘要: |
| 摘要 目的：探讨右美托咪定对颅脑损伤手术患者氧化应激反应的影响。方法：选择2014年9月至2016年9月我院接诊的92例拟行急诊手术的颅脑损伤患者，通过随机数表法分为观察组(n=46)和对照组(n=46)，观察组在诱导后给予右美托咪定的静脉注射，对照组给予相同剂量的生理盐水。比较两组术前术后血流动力学指标、血清S100β蛋白、神经元特异性烯醇化酶(NSE)、丙二醛(MDA)、超氧化物歧化酶(SOD)水平的变化。结果：观察组在给药后(T1)、插管时(T2)、拔管时(T3)、手术完成(T4)时，收缩压(SBP)、舒张压(DBP)、心率(HR)水平均显著低于对照组组(P＜0.05)；在T4、手术后6 h(T5)、手术后12 h(T6)时，观察组血清S100β、NES、MDA水平均明显低于对照组(P＜0.05)，血清SOD均明显高于对照组(P＜0.05)。结论：右美托咪定应用于颅脑损伤患者手术可有效保持手术过程中血流动力学的稳定，减轻术后氧化应激反应。 |
| 英文摘要: |
| ABSTRACT Objective: To study the effect of dexmedetomidine on the oxidative stress in patients with craniocerebral trauma operation. Methods: 92 cases of patients with brain injury undergoing emergency surgery from September 2014 to September 2016 in our hospital were selected and divided into the observation group (n=46) and the control group (n=46) according to the random number table. The observation group was given intravenous injection of dexmedetomidine after induction, the control group was given the same dose of normal saline. The hemodynamics, serum S100 beta protein, neuron specific enzyme (NSE), malondialdehyde (MDA) and superoxide dismutase (SOD) levels before and after operation were compared at different time points. Results: At administration (T1), intubation (T2), extubation (T3), operation completed (T4), the levels of systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR) of the observation group were lower than those of the control group(P＜0.05); at T4, after operation 6h(T5), after operation 12h(T6), the levels of serum S100β, NES and MDA levels of observation group were lower than those of the control group(P＜0.05), the serum SOD levels was higher than that of the control group(P＜0.05). Conclusion: Dexmedetomidine was effective for the craniocerebral trauma operation, which could effectively maintain the stability of hemodynamics during operation, reduce the oxidative stress reactions. |
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