| 谭宝利,尚 东,张进儒,郭立夫,赵 强.鸦胆子油乳、艾迪注射液对非小细胞肺癌化疗效果的影响[J].,2017,17(17):3331-3334 |
| 鸦胆子油乳、艾迪注射液对非小细胞肺癌化疗效果的影响 |
| Clinical Effect of Brucea Javanica Emulsion Oil, Aidi-injection with GP Chemotherapy in Patients with Non Small Cell Lung Cancer |
| 投稿时间：2016-09-22 修订日期：2016-10-21 |
| DOI：10.13241/j.cnki.pmb.2017.17.033 |
| 中文关键词: 非小细胞肺癌 鸦胆子油乳 艾迪注射液 GP化疗方案 |
| 英文关键词: Non small cell lung cancer Brucea javanica emulsion oil Aidi-injection GP chemotherapy |
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| 中文摘要: |
| 摘要 目的：分析鸦胆子油乳、艾迪注射液配合GP化疗治疗非小细胞肺癌的疗效及对免疫功能的影响。方法：以2010年1月至2016年3月宝鸡市解放军第三医院收治的非小细胞肺癌患者80例为研究对象，根据住院病历号顺序分为观察组和对照组，每组40例，对照组接受GP化疗方案，观察组接受GP化疗方案联合鸦胆子油乳、艾迪注射液治疗，两组均10天为一个周期，4个周期为一个疗程，均治疗1个疗程。比较两组的临床疗效、不良反应、T细胞亚群水平及生活质量评分。结果：观察组的总缓解率和疾病控制率分别为62.5%和92.5%，均显著高于对照组（47.5 %和75.0 %）（P<0.05）；治疗后，两组的CD3+、CD4+、CD8+、CD4+ /CD8+水平均较治疗前显著降低（P<0.05），观察组治疗后的CD3+、CD4+、CD8+水平均明显高于对照组（P<0.05）；两组治疗后的KPS评分均较治疗前升高，且观察组的KPS评分显著高于对照组（P<0.05）；治疗期间，观察组的恶心呕吐、腹泻、白细胞计数减少、血小板减少、肝功能损害和肾功能损害的发生率均显著低于对照组（P<0.05）；半年内，观察组的生存率(87.5%）显著高于对照组的生存率（77.5%）。结论：鸦胆子油乳、艾迪注射液配合GP化疗治疗非小细胞肺癌的疗效显著，不良反应发生率低，提高半年生存率，而且可降低化疗对T细胞亚群水平的影响，并降低患者血清VEGF水平。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinical effect of brucea javanica emulsion oil, Aidi-injection with GP chemotherapy in patients with non small cell lung cancer and the influence on immune function. Methods: 80 cases of patients with non small cell lung cancer in our hospital from January 2010 to March 2016 were divided into observation group and control group, 40 cases in each group. The patients in the control group were treated with GP chemotherapy, and the patients in the observation group were treated with brucea javanica emulsion oil, Aidi-injection with GP chemotherapy. 10 days for a cycle, four cycles for a period of treatment, treatment time of both groups were 1 course of treatment. The clinical effect, adverse effects and T cell subgroup level were compared between two groups. Results: The overall response rate and disease control rates of the observation group were significantly higher than those of the control group (P<0.05); After treatment, the levels of CD3+, CD4+, CD8+, CD4+/CD8+, VEGFof the two groups were significantly lower than before treatment (P<0.05), and these indexes were significantly higher in the observation group than those of the control group (P<0.05); After treatment, the KPS score of two groups was significantly higher than before treatment (P<0.05), and it was significantly higherin the observation group than that of the control group (P<0.05); the rate of adverse reactionsof the observation group during therapy were significantly lower than those of the control group (P<0.05); half-year survival rate of the observation group were significantly higher than that of the control group(P<0.05). Conclusion: Brucea javanica emulsion oil, Aidi-injection with GP chemotherapy can effectively improve the clinical effect, reduce the adverse reactions, and can alleviate the effects of chemotherapy on T cell subgroup level，and reduce the level of VEGF. |
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