| 李 伟,王 陆,康全利,马更平,崔永胜.孕酮对外伤性蛛网膜下腔出血患者早期MMP-9水平及微循环的影响[J].,2017,17(16):3129-3132 |
| 孕酮对外伤性蛛网膜下腔出血患者早期MMP-9水平及微循环的影响 |
| Effects of Progesterone on MMP - 9 Level and Microcirculation in Patients with Early Stage of Traumatic Subarachnoid Hemorrhage |
| 投稿时间：2016-08-24 修订日期：2016-09-21 |
| DOI：10.13241/j.cnki.pmb.2017.16.033 |
| 中文关键词: 孕酮 外伤性蛛网膜下腔出血 格拉斯哥昏迷指数GCS评分 金属基质蛋白酶-9（MMP-9） 微循环 |
| 英文关键词: Progesterone Traumatic subarachnoid hemorrhage GCS score MMP-9 Microcirculation |
| 基金项目:北京市自然科学基金项目(2008cdb145) |
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| 中文摘要: |
| 摘要 目的：探究孕酮对外伤性蛛网膜下腔出血患者早期MMP-9水平及微循环的影响。方法：收集我院神经外科收治的外伤性蛛网膜下腔出血患者70例，根据随机数字对照表分为对照组(35例)与试验组(35例)。两组均给予常规治疗，对照组患者给予静脉注射尼莫地平治疗，试验组在此基础上给予复方甲地孕酮治疗。观察并比较两组患者治疗前后格拉斯哥昏迷指数GCS评分、金属基质蛋白酶-9（MMP9）水平及微循环的变化情况。结果：两组患者入院时GCS评分、血清MMP-9水平无明显差异(P>0.05)，对照组治疗14天后GCS评分明显升高(P<0.05)，而试验组治疗7天、14天后均明显升高(P<0.05)，且试验组治疗7天、14天后GCS评分较对照组评分高(P<0.05)；两组患者治疗7天后血清MMP-9水平降低(P<0.05)，且试验组血清MMP-9水平较对照组降低(P<0.05)；两组患者治疗后微循环均有所改善，伤测大脑中动脉收缩峰流速降低(P<0.05)，试验组改善更为明显，伤测大脑中动脉收缩峰流速降低更为显著(P<0.05)。结论：孕酮对外伤性蛛网膜下腔出血患者的治疗效果明显，可能与其改善微循环，降低血清MMP-9水平有关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of progesterone on the serum MMP - 9 level and microcirculation of patients with early stage of traumatic subarachnoid hemorrhage. Methods: A total of 70 cases with traumatic subarachnoid hemorrhage from the neurosurgery department of our hospital were collected and randomly divided into the experimental group and control group with 35 cases in each group. Both groups were given conventional therapy, patients in the control group were treated by stop bleeding, dehydration, hormone and neurotrophic drugs conventional treatment, at the same time with nimodipine 10mg intravenous drip, once a day, continuous administration 14 days. Patients in the experimental group were treated on the basis of the control group with compound megestrol acetate treatment, 25 mg muscle injection, 1 time a day, continuous administration 14 days. After treatment, the GCS score, serum level of MMP9 and change of microcirculation were compared between two groups. Results: No obvious difference was found in the GCS score on admission between two groups(P>0.05). The GCS scores of on the 14th day of both groups were significantly increased after treatment(P<0.05), the serum MMP-9 level on the 7th day of both groups were significantly decreased after treatment(P<0.05), the microcirculation were obviously improved after treatment(P<0.05). The GCS scores of on the 14th day of experimental group was significantly higher than that of the control group(P<0.05), the serum MMP - 9 level was decreased, and the microcirculation improved more significantly after treatment. Conclusion: Progesterone had obvious effects on traumatic subarachnoid hemorrhage, which might be related to the improvement of microcirculation and decrease of serum MMP-9 level. |
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