| 赵旭东,蔡爱珍,郗洪庆,宋燕京,王 颐,赵华洲,李 华,陈 凛.JS-K抗肿瘤效果机制的研究进展[J].,2017,17(15):2987-2992 |
| JS-K抗肿瘤效果机制的研究进展 |
| Research Progress of JS-K as Anticancer Agents |
| 投稿时间：2016-08-15 修订日期：2016-08-30 |
| DOI：10.13241/j.cnki.pmb.2017.15.048 |
| 中文关键词: 一氧化氮 一氧化氮前体药 抗肿瘤 |
| 英文关键词: NO NO prodrug Anticancer |
| 基金项目:国家自然科学基金项目（81272698, 81672319, 81602507） |
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| 中文摘要: |
| 摘要：研究显示一氧化氮（NO）在体内参与多种信号通路的传导，在机体的肿瘤形成等多种病理和生理过程中发挥着重要作用。谷胱甘肽-S-转移酶（GSTs）在很多肿瘤的表达都是升高的，在肿瘤细胞中发挥着维持氧化还原平衡、解毒和促使肿瘤细胞发生耐药等方面的的作用；而JS-K是近年来新合成的一种一氧化氮（NO）前体药，其可以在体内被谷胱甘肽-S-转移酶（GSTs）酶解生成NO，进而发挥抗肿瘤效应。研究显示JS-K对机体的多种肿瘤都表现出明显的抑制作用，而对正常的组织则没有明显的损伤作用。由于肿瘤的组织来源不同，JS-K表现出的杀伤肿瘤的机制也不尽相同。本课题组通过广泛的文献阅读，系统地综述JS-K杀伤各系统肿瘤的作用机制，为JS-K杀伤肿瘤的进一步的机制研究提供一些有益的思路，和为将来JS-K的临床应用提供理论基础。 |
| 英文摘要: |
| ABSTRACT: Previous studies have shown nitric oxide (NO) is involved in a variety of signal pathways in vivo, and plays an impor- tant role in lots of pathological and physiological processes, such as tumorigenesis and so on. The expression of glutathione S-transferase (GSTs) is upregulated in many tumors, which plays an important role in maintaining the balance of redox, detoxification, and resistence to chemotherapeutics for the tumor cells. In recent years, a novel NO prodrug named JS-K was synthesised, and JS-K can be selectively catalysed by GSTs, then NO is released, subsequently showing the anticancer effect. Many studies have demonstrated JS-K can inhibit the growth of a broad spectrum of tumors, while sparing the normal tissue cells. The mechanisms for JS-K to kill tumor cells are not al- ways the same due to the differenrt origins of tumors in different systems. In this study, our team systemically reviewed the mechanisms for JS-K to kill tumors originating from different systems through extensive literature reading, with the purpose to providing some helpful ideas for the further study of JS-K and theoretical foundation for JS-K in the future clinical use. |
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