| 鲁基永,龚玉竹,米忠友,韦宏斌,张 宁.神经生长因子治疗急性颅脑损伤的效果及对患者神经功能的影响[J].,2017,17(14):2714-2717 |
| 神经生长因子治疗急性颅脑损伤的效果及对患者神经功能的影响 |
| Clinical Effects of Nerve Growth Factors on Treatment of Acute Craniocerebral Injury and Influence on Nerve Functions of Patients |
| 投稿时间：2016-10-25 修订日期：2016-11-20 |
| DOI：10.13241/j.cnki.pmb.2017.14.028 |
| 中文关键词: 神经生长因子 急性颅脑损伤 免疫功能 神经功能 |
| 英文关键词: Nerve growth factors Acute craniocerebral injury Immune function Nerve function |
| 基金项目:重庆自然科学基金项目（CSTC-2005BB5292） |
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| 中文摘要: |
| 摘要 目的：研究神经生长因子在急性颅脑损伤中的治疗效果及对神经功能的影响。方法：选取2014年8月至2015年7月本院收治的82例急性颅脑损伤患者，随机分为观察组和对照组，每组41例。对照组采取常规对症治疗，观察组在对照组基础上采用神经生长因子治疗。观察并比较两组患者治疗前后血清S100β，白介素-6（IL-6），髓鞘碱性蛋白（MBP）及神经元特异性烯醇化酶（NSE）水平的变化情况以及临床疗效。结果：观察组总有效率高于对照组，差异具有统计学意义（P<0.05）。与治疗前比较，两组患者治疗后血清S100β及IL-6水平均降低，差异具有统计学意义（P<0.05）；与对照组比较，观察组患者治疗后血清S100β及IL-6水平较低，差异具有统计学意义（P<0.05）；与治疗前比较，两组患者治疗后血清MBP及NSE水平均降低，差异具有统计学意义（P<0.05）；与对照组比较，观察组患者治疗后血清MBP及NSE水平较低，差异具有统计学意义（P<0.05）。结论：神经生长因子治疗急性颅脑损伤的效果显著，能够改善患者免疫功能和神经功能，值得临床推广应用。 |
| 英文摘要: |
| ABSTRACT Objective: To study the clinical effect of the nerve growth factors on the immune and nerve functions of patients with the acute craniocerebral injury. Methods: 82 cases with the acute craniocerebral injury who were treated in our hospital from August 2014 to July 2015 were selected and randomly divided into the observation group and the control group with 41 cases in each group. The patients in the control group were treated with the conventional methods, while the patients in the observation group were treated with the nerve growth factors on the basis of the control group. Then the changes of serum levels of S100β, interleukin-6 (IL-6), myelin basic protein (MBP) and neuron specific enolase (NSE) and the clinical efficacy between the two groups were observed and compared before and after the treatment. Results: The total clinical efficacy in the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05); Compared with before treatment, the serum levels of S100β and IL-6 in the two groups decreased after the treatment, and the differences were statistically significant (P<0.05); Compared with the control group after the treatment, the serum levels of S100β and IL-6 in the observation group were lower, and the differences were statistically significant (P<0.05); Compared with before treatment, the serum levels of MBP and NSE in the two groups decreased after the treatment, and the differences were statistically significant (P<0.05); Compared with the control group after the treatment, the serum levels of MBP and NSE in the observation group were lower, and the differences were statistically significant (P<0.05). Conclusion: Nerve growth factors has better clinical effects on the treatment of the acute craniocerebral injury, which can improve the immune and nerve functions of patients, and it is worthy of clinical application. |
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