| 叶雪瑞,尹 力,崔金金,吕 勃,于 波.SIRT3与细胞凋亡的研究进展[J].,2017,17(13):2586-2589 |
| SIRT3与细胞凋亡的研究进展 |
| Progress of Correlation between SIRT3 and Cells Apoptosis |
| 投稿时间：2016-04-25 修订日期：2016-05-20 |
| DOI：10.13241/j.cnki.pmb.2017.13.048 |
| 中文关键词: SIRT3 凋亡 线粒体通透性转换孔 氧自由基 |
| 英文关键词: SIRT3 Apoptosis Mitochondrial permeability transition pore Reactive oxygen species |
| 基金项目:国家自然科学基金重点项目（81330033） |
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| 中文摘要: |
| 摘要：SIRT3是哺乳动物体内"sirtuin家族"7成员之一，是一种NAD依赖的组蛋白去乙酰化酶，主要存在于线粒体内。SIRT3存在两种形式：44 kDa的长链和28 kDa的短链，其在细胞内主要通过短链SIRT3发挥作用。SIRT3通过其酶催化活性，除了可调节机体能量代谢、细胞衰老以及肿瘤形成等生命过程外，SIRT3对于细胞凋亡也起到举足轻重的调节作用。目前的研究表明，在细胞凋亡中，SIRT3可能存在双向调节作用，即通过不同的信号通路的作用，SIRT3可促进/抑制细胞凋亡而发挥一系列的生物学效应，而有关于SIRT3调节细胞凋亡更详尽的分子机制还有待深入研究。 |
| 英文摘要: |
| ABSTRACT: SIRT3 is one of the seven members of "Sirtuin family" inside the mammals. It is a kind of histone deacetylase mainly existed in the mitochondria as the dependence of NAD. SIRT3 has two kinds of forms: a long chain length of 44 kDa and a short chain length of 28 kDa, SIRT3 plays a role in the intracellular mainly through the short chain. In addition to regulates the body's energy metabolism, cell senescence and tumorigenesis of life process, SIRT3 also plays a regulatory role for apoptosis through its catalytic activ- ity of enzyme. Current research suggests that SIRT3 probably has the function of bidirectional regulation in apoptosis, it means through different signal pathway, SIRT3 can promote/inhibit apoptosis so that induces a series of biological effects, but the molecular mechanism of regulation of apoptosis is more detailed and need further research. |
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