| 杜岚岚,王 健,陈 佳,梁 树,向建文.新生儿持续性肺动脉高压患儿血浆VEGF与TGF-β1水平变化及临床意义[J].,2017,17(13):2550-2552 |
| 新生儿持续性肺动脉高压患儿血浆VEGF与TGF-β1水平变化及临床意义 |
| Change of Plasma VEGF and TGF-β1 Levels of Newborns with Persistent Pulmonary Hypertension and Its Clinical Significance |
| 投稿时间：2016-09-13 修订日期：2016-10-10 |
| DOI：10.13241/j.cnki.pmb.2017.13.039 |
| 中文关键词: 新生儿肺动脉高压 VEGF TGF-β1 肺动脉压力 |
| 英文关键词: Persistent pulmonary hypertension of newborn VEGF TGF-β1 Pulmonary artery pressure |
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| 中文摘要: |
| 摘要 目的：探讨新生儿持续性肺动脉高压(PPHN)患儿血浆血管内皮生长因子（VEGF）与转化生长因子-β1水平变化及临床意义。方法：选择2014年5月至2016年2月我院PPHN患儿（观察组）及足月正常儿（对照组）各30例，根据肺动脉压力（PAMP）将观察组患儿分为轻度（n=11），中度（n=11）及重度（n=8）。对观察组患儿进行常规治疗（NO+高频振荡通气），采用酶联免疫吸附（ELISA法）检测对照组与观察组治疗前、后血浆VEGF、TGF-β1水平，分析各指标与PAMP的相关性。结果：观察组治疗前血浆VEGF、TGF-β1与PAMP水平高于对照组，差异有统计学意义（P<0.05）；且观察组治疗后显著降低，与治疗前比较差异具有统计学意义（P<0.05）。观察组患儿血浆VEGF、TGF-β1与PAMP水平随着严重程度的增加而增加，其中重度>中度>轻度，差异具有统计学意义（P<0.05）。线性相关分析显示，血浆VEGF、TGF-β1水平均与PAMP 呈正相关（r＝0.744，r＝0.765，均P<0.05）。结论：PPHN患儿血浆VEGF、TGF-β1水平显著升高，与病情的发生发展有关 ，可用于临床疾病诊断及疗效评估。 |
| 英文摘要: |
| ABSTRACT Objective: To compare the difference of plasma vascular endothelial growth factor (VEGF) and transforming growth factor β1 (TGF-β1) in in newborns with persistent pulmonary hypertension(PPHN) and healthy newborns, and to explore the application val- ue of VEGF and TGF-β1 in the early diagnosis of PPHN. Methods: 30 cases of normal term newborns (control group) and 30 cases of PPHN (observation group) were selected in our hospital from May 2014 to February 2016, the observation group was divided into mild (n=11), moderate (n=11) and severe (n=8) according to the PPHN severity. The observation group was treated with routine treatment(NO+high frequency oscillatory ventilation), enzyme linked immunosorbent assay (ELISA method) was used to detect the plasma VEGF and TGF-β1 levels in control group and observation group before and after treatment, in the same time, tested the mean pulmonary artery pressure (PAMP) levels in two groups, then analyzed the correlation of each indexes. Results: The levels of plasma VEGF, TGF-β1 and PAMP in observation group before treatment were higher than the control group, the differences were statistically significant(P<0.05), and those indexes in the observation group after treatment decreased significantly, compared with before treatment, the differences were statistically significant(P<0.05). Linear correlation analysis showed that the levels of plasma VEGF, TGF-β1 were positively correlated with PAMP respectively(r=0.744, r=0.765, all P<0.05). Conclusion: The levels of plasma VEGF, TGF-β1 are significantly increased,which are correlated to the occurrence and development of the disease, and could be used for clinical disease diagnosis and evaluation of curative effect. |
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