| 李加德,郭 爽,李 静,金晓明.超极化激活的环核苷酸门控性阳离子通道（HCN）与疾病的相关性[J].,2017,17(10):1994-1996 |
| 超极化激活的环核苷酸门控性阳离子通道（HCN）与疾病的相关性 |
| The Correlation of Hyperpolarization-activated Cyclic Nucleotide-gate Cation Channel (HCN) and Disease |
| 投稿时间：2016-04-10 修订日期：2016-04-30 |
| DOI：10.13241/j.cnki.pmb.2017.10.051 |
| 中文关键词: 离子通道（HCN） 细胞膜 兴奋与传导 疾病 |
| 英文关键词: HCN Cell membrane Excitation and conduction Disease |
| 基金项目: |
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| 摘要点击次数: 373 |
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| 中文摘要: |
| 摘要：超极化激活的环核苷酸门控的阳离子通道（hyperpolarization- activated cyclic nucleotide-gate cation channel, HCN）是一种特殊的阳离子通道，存在于神经细胞、小肠间质细胞、窦房结细胞或心脏细胞等具有自律性的细胞膜上，是产生过度激活正离子电流的结构基础，被认为是起搏细胞的重要特征。HCN离子蛋白通道不但与细胞凋亡以及电流传导有着密切关系，而且还与多种生命活动过程密切相关，近年来，已涉及到疼痛、癫痫、心律失常、消化道系统等许多疾病，特别是有关神经系统方面的疾病，下面将超极化激活的环核苷酸门控性阳离子通道（HCN）与疾病的关系综述如下。 |
| 英文摘要: |
| ABSTRACT: Hyperpolarization-activated cyclic nucleotide-gate cation channel is a special kind of cation channels, existing in cell membrane of autonomous cells such as nerve cells, the small intestine interstitial cells, sinoatrial node cells or heart cells. It is structure foundation that produce excessive activated positive-ion current, considering to be an important characteristic of pacemaker cells. HCN channel is not only close relationship with cell apoptosis and current conduction but also related to a variety of life activities. In recent years, it has been involved in many diseases, such as pain, epilepsy, cardiac arrhythmias, digestive system, etc , especially nervous system diseases. Here to do a simple overview. |
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