| 朱 丹,焦晓民,赵 涛,史 焱,李 琳.芪苈强心胶囊对慢性心力衰竭患者血清hs-CRP，TNF-α及IL-8水平的影响及其临床疗效[J].,2017,17(10):1852-1855 |
| 芪苈强心胶囊对慢性心力衰竭患者血清hs-CRP，TNF-α及IL-8水平的影响及其临床疗效 |
| Effect of Qiliqiangxin Capsules on Serum Levels of TNF-α, hs-CRP and IL-8 in Patients with Chronic Heart Failure and Its Clinical Efficacy |
| 投稿时间：2016-10-28 修订日期：2016-11-21 |
| DOI：10.13241/j.cnki.pmb.2017.10.013 |
| 中文关键词: 慢性心力衰竭 芪苈强心胶囊 高敏C反应蛋白 肿瘤坏死因子-α 白介素-8 |
| 英文关键词: Chronic heart failure Qiliqiangxin capsule hs-CRP TNF-α IL-8 |
| 基金项目:辽宁省中医药临床学（专）科能力建设项目（2013-Lnzyxzk-04）；辽宁省科学事业公益研究基金项目（2013001012） |
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| 中文摘要: |
| 摘要 目的：探讨芪苈强心胶囊对慢性心力衰竭患者血清炎症因子水平的影响及其临床疗效。方法：选取2013年7月-2016年7月在我院接受治疗的慢性心力衰竭患者106例，随机分为对照组和研究组，每组53例。对照组患者采用常规抗心衰药物治疗，研究组患者在对照组基础上采用芪苈强心胶囊治疗。观察并比较两组患者治疗前后血清hs-CRP，TNF-α及IL-8水平、心功能指标及临床疗效。结果：研究组患者总有效率（81.1%）显著高于对照组（67.9%），差异具有统计学意义（P＜0.05）；与治疗前比较，治疗后两组患者血清hs-CRP，TNF-α及IL-8水平均降低，差异均具有统计学意义（P<0.05）；与对照组比较，研究组患者治疗后血清hs-CRP，TNF-α及IL-8水平较低，差异具有统计学意义（P<0.05）；与治疗前比较，两组患者治疗后LVESD及LVEDD均降低，而LVEF均升高，差异均具有统计学意义（P<0.05）；与对照组比较，研究组患者治疗后LVESD及LVEDD较低，而LVEF较高，差异均具有统计学意义（P<0.05）。结论：芪苈强心胶囊治疗慢性心力衰竭的临床效果显著，能够降低血清炎症因子水平，改善患者心功能指标，保护心肌细胞，值得临床推广及应用。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of Qiliqiangxin capsules on serum levels of inflammatory factors in patients with chronic heart failure and its clinical efficacy. Methods: 106 cases with chronic heart failure who were treated in our hospital from July 2013 to July 2016 were selected and randomly divided into the control group and the study group with 53 cases in each group. The patients in the control group were treated with conventional methods, while the patients in the study group were treated with Qiliqiangxin capsules on the basis of the control group. Then the serum levels of TNF-α, hs-CRP and IL-8, the heart functions of patients and the clinical efficacy between the two groups were observed and compared before and after the treatment. Results: The total effective rate of the study group was 81.1%, which was higher than 67.9% of the control group, and the difference was statistically significant (P<0.05); Compared with before treatment, the serum levels of hs-CRP, TNF-α and IL-8 decreased in the two groups after the treatment, and the differences were statistically significant (P<0.05); Compared with the control group after treatment, the serum levels of hs-CRP, TNF-α and IL-8 in the study group were lower, and the differences were statistically significant (P<0.05); Compared with before treatment, the LVESD and LVEDD decreased in the two groups after the treatment, while the LVEF increased, and the differences were statistically significant (P<0.05); Compared with the control group after treatment, the LVESD and LVEDD in the study group were lower, while the LVEF was higher, and the differences were statistically significant (P<0.05). Conclusion: Qiliqiangxin capsules has obvious clinical efficacy on the treatment of chronic heart failure which can reduce the serum levels of inflammatory factors, and improve the heart functions of patients, and it is worthy of clinical application. |
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