李 卿,王红梅,张瑜娟,刘安文,闵卫平.耗竭性T细胞在肿瘤中的作用[J].,2017,17(9):1788-1792 |
耗竭性T细胞在肿瘤中的作用 |
The Role of Exhausted T Cells in Tumor |
投稿时间:2016-04-28 修订日期:2016-05-23 |
DOI:10.13241/j.cnki.pmb.2017.09.051 |
中文关键词: 耗竭性T细胞 肿瘤 免疫负调控 免疫调控点 |
英文关键词: Exhausted T cells Tumor Negative immunoregulation Immune check point |
基金项目:国家自然科学基金项目(81160286; 91229119);江西省研究生创新基金项目(YC2014-B024) |
|
摘要点击次数: 337 |
全文下载次数: 266 |
中文摘要: |
摘要:耗竭性T细胞(exhausted T cells)是一群效应功能减弱,持续表达抑制性受体的T细胞,在肿瘤中表现为T细胞功能缺陷状态,主要特征为一系列抑制性受体表达增加及细胞因子分泌减少。耗竭性T细胞主要通过细胞表面的抑制性分子,细胞因子和免疫调节细胞类型改变等参与肿瘤免疫负调控,从而引起肿瘤免疫逃逸。而T细胞耗竭状态并非不可逆转,应用相应单克隆抗体靶向免疫调控点可以有效逆转耗竭性T细胞,恢复机体抗肿瘤免疫反应,提高肿瘤控制率。因此,通过逆转肿瘤患者体内的耗竭性T细胞可能是肿瘤免疫治疗的新途径之一。 |
英文摘要: |
ABSTRACT: T cell exhaustion is defined by poor effector function, sustained expression of inhibitory receptors and decrease of cy- tokine. It is a state of T cell dysfunction that arises during cancer. T cell exhaustion is associated with negative immunoregulatory path- ways which can be grouped into three main categories: cell surface inhibitory receptors, cytokine and immunoregulatory cell types. It can induce immune escape in tumor. But exhausted T cells is not irreversible. Blocking the appropriate pathways with monoclonal antibody may reverse the dysfunction of exhausted T cells, improve the anti-tumor immunity and tumor control probability. It is a new im- munotherapy to treat cancer by reversing the exhausted T cells in cancer patients. |
查看全文
查看/发表评论 下载PDF阅读器 |
关闭 |