| 史胜哲,杨延超,李 阳,李秀艳,朱俊超.电针内关对冠心病患者围术期细胞炎性因子的影响[J].,2017,17(9):1659-1662 |
| 电针内关对冠心病患者围术期细胞炎性因子的影响 |
| Influence of Electroacupuncture on the Perioperative Inflammatory Cytokines in Patients with Coronary Heart Disease |
| 投稿时间：2016-09-26 修订日期：2016-10-23 |
| DOI：10.13241/j.cnki.pmb.2017.09.015 |
| 中文关键词: 电针 内关 冠心病 白细胞介素-1β 白细胞介素-6 肿瘤坏死因子-α |
| 英文关键词: Electroacupuncture Neiguan Coronary heart disease IL-1β IL-6 TNF-α |
| 基金项目:中国医科大学附属盛京医院三新项目（2015PS57J）；辽宁省自然科学基金项目（20102282） |
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| 中文摘要: |
| 摘要 目的：探讨电针刺激内关穴对冠心病患者围术期细胞炎性因子的影响。方法：选取择期行开腹全子宫及双附件切除术的冠心病患者60例，并将患者随机分为E组(电针组)、C组(对照组)，E组用韩式电针刺激仪(HANS-B100B)在麻醉诱导前20 min开始针刺内关穴，并维持针刺至术毕，C组不做任何处理。两组患者分别记录插管前(T0)、插管后即刻(T1)、手术结束时(T2)、拔管后即刻(T3)、拔管后10 min(T4)时的血压(SBP)、平均动脉压(MAP)、心率(HR)，并留T0～T4时刻的静脉血，采用酶联免疫吸附法(ELISA)检测血清IL-1β、IL-6、TNF-α的水平。结果：两组患者组内比较：E组各时点SBP、HR、MAP较同组T0时点比较差异无统计学意义(P>0.05)，C组T1-T4时点HR、SBP、MAP较同组T0时点明显升高(P<0.05)；组间比较：E组T1-T4时HR、SBP、MAP、明显低于C组(P<0.05)，E组患者T1～T4静脉血中的IL-1β、IL-6、TNF-α均明显低于C组(P<0.05)。结论：电针刺激内关穴能抑制冠心病患者围术期的炎性反应改善心肌缺血，对心肌的保护作用显著。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of electroacupuncture of neiguan on the perioperative inflammatory cytokines lev- els of patients with coronary heart disease. Methods: 60 cases of patients with coronary heart disease (CHD) underwent elective laparotomy hysterectomy and bilateral salpingo resection operation were selected and randomly divided into the group E (EA group), group C (con- trol group) and group E with Korean electroacupuncture stimulation instrument (HANS-B100B) in 20 min before the induction of anes- thesia to acupuncture at Neiguan (PC 6), and to maintain the acupuncture to postoperative, group C without any treatment. The blood pressure (SBP), mean arterial pressure (map), heart rate (HR) of both groups were recorded before intubation (T0), after intubation imme- diately (T1), operation end (T2) and extubation after immediately (T3), extubation after 10 min (T4), and leave a T0 ~ T4 moments of ve- nous blood by enzyme linked immunosorbent method (ELISA) to detect the serum levels of IL-1β, IL-6, TNF-α concentration. Results: The difference between the two groups of patients compared with group E of SBP, MAP, HR is in the same group T0 no statistical signif- icance (P>0.05), group C T1-T4 point of HR, MAP, SBP than the same group T0 increased significantly (P<0.05); group compared E T1-T4 Group HR, SBP, MAP significantly lower than in group C (P<0.05), E group of patients with T1 ~ T4 venous blood of IL-1, IL-6, TNF-α were significantly lower than in group C (P<0.05). Conclusion: Electroacupuncture can inhibit the inflammatory response in pa- tients with coronary heart disease during perioperative period and improve the protective effect of myocardial ischemia. |
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