| 朴仁女,赵 冬,阚 亮,汪 磊,郑美玲.奥美拉唑联合克拉霉素、阿莫西林对老年消化性溃疡患者胃泌素水平与外周血红细胞免疫功能的影响[J].,2017,17(8):1509-1512 |
| 奥美拉唑联合克拉霉素、阿莫西林对老年消化性溃疡患者胃泌素水平与外周血红细胞免疫功能的影响 |
| Effect of Omeprazole Combined with Clarithromycin and Amoxicillin on Gastrin Levels and Peripheral Blood Red Cell Immune Function of Elderly Patients with Peptic Ulcer |
| 投稿时间：2016-10-30 修订日期：2016-11-21 |
| DOI：10.13241/j.cnki.pmb.2017.08.027 |
| 中文关键词: 奥美拉唑 阿莫西林 克拉霉素 消化性溃疡 |
| 英文关键词: Omeprazole Amoxicillin Clarithromycin Peptic ulcer |
| 基金项目:辽宁省卫生厅科研项目(2013125) |
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| 中文摘要: |
| 摘要 目的：探讨奥美拉唑联合克拉霉素、阿莫西林对老年消化性溃疡患者胃泌素水平与外周血红细胞免疫功能的影响。方法：收集我院就诊的100例消化性溃疡患者，随机分为实验组和对照组，每组50例。对照组患者给予奥美拉唑肠溶片治疗；实验组患者给予奥美拉唑肠溶片、克拉霉素及阿莫西林胶囊治疗。观察并比较两组患者治疗前后胃泌素（Gastrin）、红细胞免疫功能（RBC-C3b、RBC-ICRRR）水平、临床疗效及不良反应。结果：与治疗前相比，两组患者治疗后胃泌素、RBC-ICRRR水平均下降，RBC-C3b水平均升高，差异具有统计学意义（P<0.05）；与对照组相比，实验组患者治疗后胃泌素、RBC-ICRRR水平较低，RBC-C3b水平较高，差异具有统计学意义（P<0.05）；实验组患者治疗总有效率高于对照组，差异具有统计学意义（P<0.05）；两组患者不良反应发生率相比，差异无统计学意义（P>0.05）。结论：奥美拉唑联合克拉霉素、阿莫西林能够降低老年消化性溃疡患者胃泌素水平，改善红细胞免疫功能，临床疗效较好。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the effect of omeprazole combined with clarithromycin and amoxicillin on gastrin levels and the peripheral blood red cell immune function of elderly patients with peptic ulcer. Methods: 100 cases of peptic ulcer in our hospital were randomly divided into the experimental group and the control group, with 50 cases in each group. The patients in the control group were treated with omeprazole enteric, while the patients in the experimental group were treated with the omeprazole enteric, clarithromycin and amoxicillin. Then the levels of gastrin, RBC-C3b and RBC-ICRRR and the clinical curative effect and adverse reactions in the two groups were observed and compared before and after the treatment. Results: Compared with before treatment, the levels of gastrin and RBC-ICRRR in the two groups decreased after the treatment, and the levels of RBC-C3b increased, and the differences were statistically significant (P<0.05); Compared with the control group, the levels of gastrin and RBC-ICRRR in the experimental group were lower, and the level of RBC-C3b was higher, and the differences were statistically significant (P<0.05); The total clinical efficacy in the experimental group was higher than that of the control group, and the difference was statistically significant (P<0.05). There was no statistically significant difference about the adverse reactions between the two groups (P>0.05). Conclusion: The combination of the omeprazole, clarithromycin and amoxicillin has better effects on the treatment of peptic ulcer, which can reduce the levels of gastrin and RBC-ICRRR, as well as increase the levels of RBC-C3b. |
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