| 宁 超,雷冬玉,魏媛媛,蒙克嘎勒,李 静,王丽凤,杜 靖.鞣花酸预防高脂饮食诱导的大鼠肥胖的作用研究[J].,2017,17(8):1420-1424 |
| 鞣花酸预防高脂饮食诱导的大鼠肥胖的作用研究 |
| Anti-obesity Function of Ellagic Acid on High-fat Diet-induced Rats |
| 投稿时间：2016-11-09 修订日期：2016-11-24 |
| DOI：10.13241/j.cnki.pmb.2017.08.005 |
| 中文关键词: 鞣花酸 预防肥胖 大鼠 体重 |
| 英文关键词: Ellagic Acid Obesity prevention Rats Body weight |
| 基金项目:国家自然科学基金项目（81460636） |
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| 摘要点击次数: 704 |
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| 中文摘要: |
| 摘要 目的：研究鞣花酸对高脂饮食引起的大鼠肥胖预防的影响。方法：将40只SD 雄性大鼠按体重随机分为鞣花酸高剂量组（高脂饮食 + 30 mg/kg/d 鞣花酸，EAH），鞣花酸低剂量组(高脂饮食 + 10 mg/kg/d 鞣花酸，EAL），阳性对照组（高脂饮食 + 37.8 mg/kg/d 奥利司他，O），模型对照组（高脂饮食 + 10 mL/kg/d 0.5 % CMC钠溶液，HFD）和空白对照组（普通饮食 + 10 mL/kg/d 0.5 % CMC钠溶液，ND），连续给药10周，测量体重、进食量、体脂、肝重、肾重，计算脏器系数和脂肪系数，测定血清总胆固醇（TC），甘油三酯（TG），低密度脂蛋白胆固醇（LDL - C）和高密度脂蛋白胆固醇(HDL - C)；HE染色观察脂肪细胞和肝脏组织细胞形态。结果：干预10周后，与模型对照组比较，鞣花酸高、低剂量组大鼠体重和进食量均显著下降（P ＜0.05），脂肪系数显著降低（P ＜0.001）；鞣花酸高、低剂量组血清HDL-C增加（P ＜0.01），鞣花酸高剂量组血清TC降低 ( P ＜0.05)；HE染色观察发现鞣花酸高、低剂量组脂肪细胞直径显著变小，肝组织脂滴空泡明显减少，且呈剂量依赖性。结论：鞣花酸可能通过抑制高脂饮食大鼠的摄食量从而抑制其体重的增加。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of Ellagic Acid on obesity prevention. Methods: Forty male SD rats were randomly divided into 5 groups ( n = 8 ) as follows: rats fed with HF diet with high dosage of Ellagic Acid( 30 mg/kg/d , EAH group), rats fed with HF diet with low dosage of Ellagic Acid ( 10 mg/kg/d, EAL group), rats fed with HF diet with Orlistat Capsules( 37.8 mg/kg/d , O group), rats fed with HF diet with placebo pellet(0.5 % CMC Na solution, 10 mL/kg/d , HFD group), and rats fed with normal diet with placebo pellet(0.5 % CMC Na solution, 10 mL/kg/d , ND group) for 10 weeks. Body weight, food intake, the index of body adipose tissue, liver and kidney were measured. The serum lipid level of TG, TC, HDL-C and LDL-C were analyzed. Adipocyte and liver cells were examined under a light microscope after HE staining. Results: Ellagic Acid high and low dosage could significantly decrease body weight, food intake and body adipose tissue index compared with HFD group (P < 0.05). All dosage of Ellagic Acid could significantly increase serum HDL-C（P < 0.01 or P < 0.05）, and the high dose Ellagic Acid could significantly decrease serum TC（P < 0.05）. The size of lipocytes of adipose tissue and the number of lipid droplet of liver of the high and low dosage of Ellagic Acid became smaller and littler. Conclusion: Ellagic acid could significantly inhibit body weight by inhibiting food intake in rats fed with high fat diet. |
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