| 辛艳 赵晓晶 李季 杨兰雪 何秀萍△.miRNA-200 家族在卵巢癌中作用的研究进展[J].,2017,17(7):1387-1389 |
| miRNA-200 家族在卵巢癌中作用的研究进展 |
| Research Progress on the Effect of miRNA-200 Family on Ovarian Cancer |
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| DOI： |
| 中文关键词: miRNA-200 卵巢癌 诊断 预后 |
| 英文关键词: miRNA-200 Ovarian cancer Diagnosis Prognosis |
| 基金项目: |
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| 中文摘要: |
| MicroRNA(miRNA)是一类非编码小分子RNA，参与基因转录后水平调控，与肿瘤的形成、侵袭及转移、治疗及预后过程密
切相关。研究发现，miRNA-200 家族包括miR-141、miR-200a、miR-200b、miR-200c 和miR-429 在卵巢癌中的表达改变明显，且参
与卵巢癌的发生、侵袭转移、卵巢癌细胞对紫杉醇的敏感性及复发过程，可能是用于卵巢癌的早期诊断、治疗、预后预测的指标。
本文主要对miRNA-200 家族在卵巢癌中的研究进展进行综述。 |
| 英文摘要: |
| MicroRNAs (miRNAs) was a group of small non coding RNA, which was involved in the regulation of gene transcription,
and participated in the process of tumor formation, invasion and metastasis, treatment and prognosis. It was showed that the expressions
of miRNA-200 family including miR-141, miR-200a,miR-200b, miR-200c and miR-429 in ovarian cancer were obviously
changed, rand closely related to the ovarian tumorigenesis, invasion and metastasis, paclitaxel resistance and relapse. So they were expected
to be used in the early diagnosis, treatment and prognostic of ovarian cancer. This paper reviewed the research progress of miRNA-
200 family on ovarian cancer. |
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