| 乔昱婷 郭力 孙润珠 王化宁 张瑞国 彭正午△.奥氮平联合重复经颅磁刺激或改良电休克治疗精神分裂症的疗效分析[J].,2017,17(7):1247-1250 |
| 奥氮平联合重复经颅磁刺激或改良电休克治疗精神分裂症的疗效分析 |
| Effects of Olanzapine Combined with Repetitive Transcranial MagneticStimulation or Modified Electric Convulsive Therapy on Schizophrenia |
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| DOI： |
| 中文关键词: 奥氮平 改良电休克治疗 重复经颅磁刺激 精神分裂症 临床疗效 |
| 英文关键词: Olanzapine MTCT rTMS Schizophrenia Clinical efficacy |
| 基金项目:国家自然科学基金项目（81571309；81401109） |
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| 中文摘要: |
| 目的：比较抗精神病药物奥氮平联合复经颅磁刺激(rTMS)或改良电休克(MECT)治疗精神分裂症的疗效。方法：将84 例精神
分裂症患者随机分为rTMS 组(42 例)与MECT 组(42 例)，两组分别在奥氮平的基础上联合MECT 或rTMS进行治疗。在治疗2、
4、8 周末后，采用阳性症状和阴性症状量表PANSS、治疗时出现症状量表TESS评估临床治疗效果及不良反应，同时采用修订韦
氏记忆量表(WMS-RC)和威斯康星卡片分类测验(WCST)评定认知功能。结果：治疗后，两组总有效率比较无统计学差异(P>0.05)。
两组治疗后PANSS总分、阳性症状、阴性症状和一般病理分值均显著低于治疗前(P<0.05，P<0.01)，但组间比较无统计学差异
(P>0.05)。两组TESS评分及不良反应的发生情况比较无统计学差异(P>0.05)。与治疗前相比，两组患者治疗后认知功能均显著改
善(P<0.05，P<0.01)，且rTMS联合组在改善患者记忆功能、执行能力方面效果优于MTCT 组(P < 0.05)。结论：奥氮平联合MECT
或rTMS对精神分裂症状的疗效相当，但联合rTMS可更显著改善患者的认知功能。 |
| 英文摘要: |
| Objective:To compare the effects of olanzapine combined with repetitive transcranial magnetic stimulation (rTMS) or
modified electric convulsive (MECT) therapy on schizophrenia.Methods:A total of 84 cases of patients with schizophrenia were collected
and divided into the olanzapine plus MECT (n=42) and the olanzapine plusrTMS group (n=42). The positive and negative symptom
scale (PANSS) was used to evaluate the efficacy at the end of 2nd, 4th and 8th week after treatment. The adverse reactions Scale (TESS)
was introduced to evaluate the adverse reactions. The cognitive function was evaluated with Weschler Memory Scale (WMS) and Wisconsin
Card Test (WCST).Results:There was no significant difference in the total effective rate, total score of PANSS, positive symptoms,
negative symptoms and general pathological symptoms betwwen MECT and rTMS group (P>0.05). But the total score of PANSS,
positive symptoms, negative symptoms and general pathological symptoms were significantly decreased (P<0.05, P<0.01) after treatment.
There was no significant difference in the incidence of adverse reactions between rTMS and MECT group (P>0.05). However, the
cognition was obviously ameliorated following treatment with olanzapine plus rTMS or MECT (P<0.05, P<0.01). and higher improvement
in memory and execution capacity was observed in olanzapine plus rTMS groups, when compared with olanzapine plus MECT
group (P<0.05).Conclusion:The combined application of olanzapine with rTMS or MECT had the similar efficacy in the treatment of
schizophrenia, but the former exhibited the higher therapeutic effect on the improvement of cognitive function. |
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