| 李旭忠 吴德龙 姜龙 林凤琴 许香香.右美托咪啶与咪达唑仑在重症破伤风患者镇静中效果比较[J].,2017,17(6):1160-1162 |
| 右美托咪啶与咪达唑仑在重症破伤风患者镇静中效果比较 |
| Comparison of Dexmedetomidine and Midazolamfor Sedation Effect inPatients with Severe Tetanus |
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| DOI： |
| 中文关键词: 右美托咪啶 咪达唑仑 重症破伤风 镇静 |
| 英文关键词: Dexmedetomidine Midazolam Severe tetanus Sedation |
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| 中文摘要: |
| 目的：比较右美托咪啶与咪达唑仑用于重症破伤风患者镇静中效果。方法：选取2012年1 月~2015 年12 月间在我院治疗的
重症破伤风患者72 例，通过随机数表法分为右美托咪啶组与咪达唑仑组，各36例，给予右美托咪啶组静脉泵入右美托咪啶1
滋g/kg，持续时间为10 min，之后以0.3~0.6 滋g/kg进行维持，咪达唑仑组静脉泵入咪达唑仑0.05 mg/kg，持续时间为1 min，之后以
0.02~0.1/kg·h 进行维持。监测两组患者用药前及用药12 h 后平均动脉压（MAP）、呼吸频率（RR）、血氧饱和度（SpO2）和心率
（HR）；采用Ramasy评分法评估镇静程度。结果：两组患者治疗后HR、RR、MAP 水平明显降低，而SpO2明显上升，且右美托咪啶
组HR、RR、及SpO2改善更显著，差异均有统计学意义（P<0.05）；两组用药后4 h、8 h、12 h时Ramasy 评分在组间、组内比较差异
均无统计学意义（P>0.05）；右美托咪啶组不良反应发生率为5.56%，低于咪达唑仑组的16.67%，差异有统计学意义（P<0.05）。结
论：右美托咪啶有助于维持患者血流动力学的稳定，减少重症破伤风患者心动过速、心率增快、呼吸抑制等不良反应情况的发生。 |
| 英文摘要: |
| Objective:To compare the Dexmedetomidine and Midazolam for sedation effect in patients with severe tetanus.Methods:Selected 72 patients with severe tetanus treated in our hospital from January 2012 to December 2015, who were divided into
Dexmedetomidine group and Midazolam group, with 36 cases in each group through random number table method. Given the
Dexmedetomidine group intravenous infusion Dexmedetomidine 1 ug/kg, duration 10 min and then keep in 0.3~0.6 ug/kg, and the
Midazolam group given intravenous infusion of Midazolam 0.05 mg/kg, duration 1 min, then to 0.02~0.1 ug/kg be maintained. Mean
arterial pressure(MAP), respiratory rate (RR), oxygen saturation(SpO2) and heart rate(HR)in two groups before and 12 h after treatment
were monitored; Ramasy grading method is used to evaluate sedation degree.Results:HR, RR, MAP were significantly decrease, while
the SpO2 were significantly increased in two groups after treatment (P<0.05), and the SpO2, HR, RR in Dexmedetomidine group after
treatment improved more than Midazolamgroup, the differences were statistically significant(P<0.05). Ramasy score within and between
two groups 4 h, 8 h,12 h after treatment had no statistically significant difference (P>0.05). The incidence of adverse reactions in
Dexmedetomidine groupwas was 5.56%, which was less than 16.67% in Midazolam group, the difference was statistically significant
(P<0.05).Conclusion:Dexmedetomidine helps maintain hemodynamic stability, reducing the incidence of adverse reactions such as
tachycardia, increased heart rate, respiratory depression and others in patients with severe tetanus. |
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