| 郝建慧,姚盛波,李旭光,樊 莉,刘 艳.盐酸右美托咪定抗心律失常的研究进展[J].,2017,17(5):985-988 |
| 盐酸右美托咪定抗心律失常的研究进展 |
| Research Progress on the Antiarrhythmic Effect of Dexmedetomidine |
| 投稿时间：2016-04-05 修订日期：2016-04-30 |
| DOI：10.13241/j.cnki.pmb.2017.05.050 |
| 中文关键词: 盐酸右美托咪定 心律失常 心肌保护 α2肾上腺素能受体 |
| 英文关键词: Dexmedetomidine Arrhythmia Myocardial protection α2-adrenergic receptor |
| 基金项目:国家自然科学基金创新研究群体科学基金项目（81121003） |
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| 中文摘要: |
| 摘要：心律失常是心血管系统的常见病症之一，其发病率和致死率均极高，是心源性猝死的主要诱因。因此，抗心律失常药物的研究与开发已成为医药领域的研究热点。盐酸右美托咪定是一种高选择性α2肾上腺素受体激动剂，广泛应用于重症监护患者的镇静，镇痛及维持血流动力学稳定等方面。近年来，据临床报道，盐酸右美托咪定对先天性心脏病术中及术后常反复发生的交界逸搏性心动过速、房性异位性心动过速、折返性室上性心动过速、室性及室上性心动过速等快速性心律失常具有良好的治疗作用，还可以减轻围术期心肌损伤，有效地维持血流动力学稳定。本文就应用盐酸右美托咪治疗心律失常的研究进展进行阐述。 |
| 英文摘要: |
| ABSTRACT: Cardiac arrhythmia is one of the most common cardiovascular diseases with high morbidity and mortality, and has been a major cause of sudden cardiac death. Dexmedetomidine, a highly selective α2-adrenergic receptor agonists, is now widely used in the intensive care setting for sedation, analgesia and hemodynamic stability. In recent clinical reports, dexmedetomidine shows a benefi- cial therapeutic role in junctional ectopic tachycardia(JET), atrial ectopic tachycardia(AET), reentry type supraventricular tachycardia (Re-SVT), atrial flutter (AF) or ventricular and supraventricular tachyarrhythmias during the perioperative period for congenital cardiac surgery. It also reduces perioperative myocardial injury, and then effectively maintains hemodynamic stability. Understanding its mecha- nism of these effects may provide a new strategy for the development of antiarrhythmic drugs, to achieve the purpose of translational medicine. |
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