| 姜 维,陈 曦,胡 娜,赵 美,刘新友.川芎当归不同配伍对偏头痛大鼠体内5-HT, NO和NOS的影响研究[J].,2017,17(5):830-834 |
| 川芎当归不同配伍对偏头痛大鼠体内5-HT, NO和NOS的影响研究 |
| Study on the Effects of Ligusticum wallichii with Different Proportion of Angelica Sinensis on the Contents of Endogenous Substances in Migraine Rats |
| 投稿时间：2016-08-29 修订日期：2016-09-13 |
| DOI：10.13241/j.cnki.pmb.2017.05.007 |
| 中文关键词: 川芎当归药对 偏头痛 5-HT NO NOS |
| 英文关键词: Ligusticum wallichii-Angelica sinensis Migraine 5-HT NO NOS |
| 基金项目:陕西省中医药管理局项目(13-ZY039) |
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| 中文摘要: |
| 摘要 目的：研究不同比例的川芎当归配伍对偏头痛大鼠体内内源性物质影响。方法：采用雄性SD大鼠，皮下注射硝酸甘油混悬液制作偏头痛大鼠模型，以偏头痛模型大鼠体内三种内源性物质5-HT、NO和NOS含量为考察指标，观察给予川芎-当归不同配比（1:9,2:8~9:1）提取液后，模型大鼠体内5-HT、NO和NOS含量变化。结果：在不同配伍比例川芎当归给药后，模型大鼠脑内5-HT含量随川芎比例增加而增加，当川芎比例超过5:5是变化显著，达到8:2时变化最显著；NO而NOS含量变化差异不显著。结论：川芎当归药预防给药对能够减少脑内5-HT在偏头痛发作时的消耗，发挥收缩血管作用，且随着川芎比例增大，作用逐渐增强；阿魏酸对偏头痛的预防有效，但不是唯一有效成分，不能作为药对作用的决定因素。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of different proportion of Chuanxiong-danggui on endogenous substances of mi- graine rats. Methods: Subcutaneous injection of nitroglycerine suspension was used to establish the migraine rats. Changes in contents of three endogenous substances including 5-HT, NO and NOS in migraine rats were tested to observe the effects of different ration（1:9,2:8~9:1）of Ligusticum wallichii- Angelica sinensis extracts on migraine rats. Results: After administration with different ration of herb pairs mentioned above, content of 5-HT in brain of model rats was increased markedly following the increasing ration of Chuanxiong. This phenomenon occurred while the ration of Ligusticum wallichii exceed 5:5, especially it reached to 8:2; while there was no signifi- cant difference in contents of NO and NOS. Conclusion: Prophylactic administration of Chuanxiong-Danggui could decrease the 5-HT consumption during migraine fit, and then constricts blood vessels. Moreover, this function strengthend gradually with the increasing pro- portion of Ligusticum wallichii. Ferulic acid is effective on migraine, yet it is not the only effective component, thus it cannot be the func- tion decisive factor. |
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