| 周磊 范茂丹 郑成刚 衣洪杰 刘青乐.代谢组学在一氧化碳中毒研究的应用和展望[J].,2017,17(3):572-574 |
| 代谢组学在一氧化碳中毒研究的应用和展望 |
| Application and Prospects of Metabolomics in the Study of Carbon Monoxide Poisoning |
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| DOI： |
| 中文关键词: 代谢组学 高压氧 一氧化碳中毒 |
| 英文关键词: Metabolomics Hyperbaric oxygen Carbon monoxide poisoning |
| 基金项目:杭州市医药卫生科研基金项目（20150133x05） |
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| 中文摘要: |
| 一氧化碳中毒是常见的以中枢神经系统损害为主的全身性疾病。一氧化碳作为一个脂溶性分子，进入细胞内造成组织缺
氧。一氧化碳是否可以诱导产生其他特定的生物学效应，还需要我们去研究。代谢组学是继基因组学、转录组学、蛋白质组学后的
又一新兴学科，在肿瘤、糖尿病、冠心病、肥胖症、脑卒中等多种临床疾病的相关研究中显示出巨大的潜力。将代谢组学技术应用
到一氧化碳中毒研究中，可以加深对一氧化碳中毒发病机制的认识，丰富早期诊断方法，改善治疗效果的监测手段。但代谢组学
技术在一氧化碳中毒研究中的应用仍是凤毛麟角，我们在此对代谢组学在一氧化碳中毒研究中应用及前景作一展望。 |
| 英文摘要: |
| Carbon monoxide poisoning was a systemic disease which mainly damaged the central nervous system. Carbon
monoxide entered cells as a fat-soluble molecule which caused tissue hypoxia. If carbon monoxide could cause other biological effects
awaited us to research. Metabolomics was a up-and-coming subject following genomics, transcriptomics, proteomics, which showed
great potential in the research of a variety of clinical disease, such as cancer, diabetes, coronary heart disease, obesity, stroke. We could
deepen our understanding of the pathogenesis, improve the early diagnosis, and enrich the monitoring means of the effects of treatments
to carbon monoxide poisoning by appling metabolomics to the studies of carbon monoxide poisoning. But the application of
metabolomics technique in the studies of carbon monoxide poisoning was rare. Its role and research prospects in the research of carbon
monoxide poisoning were looked forward as follows. |
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