| 苏兰 秦爱兰 冯婷婷 邹婷 甘建和 赵卫峰.自身免疫性肝病患者外周血Th1/Th2 细胞的表达及其与肝功能的相关性研究[J].,2017,17(3):476-480 |
| 自身免疫性肝病患者外周血Th1/Th2 细胞的表达及其与肝功能的相关性研究 |
| Expressions of Th1 and Th2 cells in Patients with Autoimmune Liver Disease(AILD) and their Correlation with the Liver Function |
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| DOI： |
| 中文关键词: 自身免疫性肝病 辅助T 细胞1 辅助T 细胞2 肝功能 相关性研究 |
| 英文关键词: Autoimmune Liver Disease T help 1 cells T help 2 cells Liver function Correlation study |
| 基金项目:江苏省科技支撑计划-社会发展项目（BE2010650） |
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| 中文摘要: |
| 目的：探讨自身免疫性肝病(AILD)患者外周血中辅助T细胞1(Th1)和辅助T细胞2(Th2)的表达情况及其与肝功能的相关
性。方法：选择42 例AILD 患者为实验组，11 例健康体检者作为对照组，采用流式细胞术检测实验组和对照组外周血单个核细胞
中Th1 和Th2 细胞在淋巴细胞亚群中所占百分率，并检测患者肝功能，分析Th1、Th2 细胞水平与肝功能血清生化指标的相关性。
结果：AILD 组患者Th1 细胞和Th2 细胞百分率均高于健康对照组(P<0.05)；AILD 活动期患者Th1 和Th2 细胞百分率明显高于
健康对照组，AILD 缓解期患者外周血淋巴细胞亚群中Th1 细胞所占比例明显降低，Th2 细胞百分率较健康人群高，Th1/Th2 比值
明显降低。AILD患者Th1 细胞百分率与血清中TBIL、DBIL、GGT 水平呈正相关关系(r 分别为0.428、0.472、0.511，P 值分别为
0.010、0.004、0.002)。Th1/Th2 比值与血清中TBIL、DBIL 水平呈正相关关系(r 分别为0.424、0.405，P 值分别为0.011、0.016)。结论：
AILD患者Th1细胞和Th2细胞百分率异常升高，且Th1细胞百分率及Th1/Th2比率与AILD患者肝功能指标具有良好的相关性。 |
| 英文摘要: |
| Objective:To examine the expressions of Th1 and Th2 cells and their correlation with the liver function in peripheral
blood of patients with Autoimmune Liver Disease (AILD).Methods:We collected the peripheral blood from 42 cases of Autoimmune
Liver Disease and 11 healthy volunteers. The proportion of Th1 and Th2 cells in peripheral blood lymphocyte (PBL) subsets were assessed
by Flow Cytometric analysis, and we examined liver function indicators and analyzed the correlation between Th1 and Th2 cells
and liver function serum biochemical parameters.Results:The percentages of Th1 and Th2 cells in AILD group were both higher than
the healthy controls (HC)(P<0.05). The percentages of Th1 and Th2 cells of patients in active phase of AILD were significantly higher
than the healthy controls. In the remission stage, the percentages of Th1 cells in peripheral blood lymphocyte (PBL) subsets in AILD
group decreased obviously, the percentages of Th2 cells were higher than the healthy controls. And the ratios of TH1/TH2 in AILD remission
group decreased obviously than the healthy controls. The percentages of Th1 cells in AILD group were positively correlated with
TBIL, DBIL and GGT level (r=0.428, 0.472 and 0.511, P=0.010,0.004 and 0.002). The ratios of TH1/TH2 were positively correlated with
TBIL and DBIL level (r=0.424 and 0.405, P=0.011 and 0.016).Conclusion:The percentages of Th1 and Th2 cells in AILD patients abnormally
elevated, besides the percentages of Th1 cells and the ratios of TH1/TH2 were positively correlated with liver function parameters. |
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