| 贾一平 赵仙先△ 吴弘 朱嘉琦 沈健.原发性高血压患者血压昼夜节律与靶器官损害的关系研究[J].,2017,17(3):473-475 |
| 原发性高血压患者血压昼夜节律与靶器官损害的关系研究 |
| Relationship between Circadian Rhythmof Blood Pressure and Target OrganDamage in Patients with Essential Hypertension |
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| DOI： |
| 中文关键词: 原发性高血压 靶器官 损伤 血压昼夜节律 |
| 英文关键词: Essential hypertension Target organ Damage Circadian rhythmof blood pressure |
| 基金项目: |
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| 中文摘要: |
| 目的：研究原发性高血压患者血压昼夜节律异常是否与靶器官损害存在关联。方法：将2015 年2~11 月份在我院治疗的94
例原发性高血压病人按照血压昼夜节律是否正常分为节律正常组52 例和异常组42 例。比较两组患者的24h、白天、夜间的收缩
压(SBP)与舒张压(DBP)及血压负荷，并且比较两组患者心脏、脑、肾损伤相关指标。结果：异常组全天24h、白天、夜间SBP 及
DBP，血压负荷均高于正常组，差异具有统计学意义（P<0.05）。异常组患者左室重量(LVM)和左室重量指数(LVMI)、发生心肌缺血
次数及持续时间、发生脑梗死几率均明显高于正常组，差异有统计学意义（P<0.05）。异常组尿微量白蛋白( MAU)、尿酸( UA)水平
均高于正常组，差异有统计学意义（P<0.05）。结论：原发性高血压患者出现昼夜节律异常，可能对相关靶器官造成损伤。 |
| 英文摘要: |
| Objective:To investigate relationship between the circadian rhythm of blood pressure and target organ damage in essential
hypertension patients.Methods:94 patients with essential hypertension in our hospital from February to November of 2015 were
divided into normal group (52 cases) and abnormal group (42 cases) according to whether the circadian rhythm of blood pressure was
normal. The systolic blood pressure (SBP), diastolic blood pressure (DBP) and blood pressure load were compared between the two
groups at 24 h, day and night.Meanwhile, the heart and brain damage indexes were compared between the two groups.Results:The SBP
and DBP at 24, day, night and blood pressure load in abnormal group were higher than normal group (P<0.05). The levels of left ventricular
mass (LVM) and left ventricular mass index (LVMI), frequency and duration of myocardial ischemia, incidence of cerebral infarction
in abnormal group were higher than normal group (P<0.05). The levels of microscale albuminuria (MAU) and uric acid (UA) in the abnormal
group were higher than those in the normal group (P<0.05).Conclusion:Circadian rhythmof blood pressure abnormality appeared
in patients with essential hypertension may damage the related target organ. |
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