| 薛潇迪 檀亚航 杨晓波 杨俊杰 陈韵岱.绝经女性冠状动脉钙化积分与臂踝动脉脉搏波传导速度的相关性研究[J].,2017,17(3):443-446 |
| 绝经女性冠状动脉钙化积分与臂踝动脉脉搏波传导速度的相关性研究 |
| Association between Coronary Artery CalciumScoring and Brachial AnklePulse Wave Velocity in Post-menopause Women |
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| DOI： |
| 中文关键词: 绝经 钙化积分 臂踝动脉脉搏波传导速度 |
| 英文关键词: Post-menopause Coronary artery calciumscoring Brachial Ankle Pulse Wave Velocity |
| 基金项目:国家自然科学基金项目（81270186,81400229） |
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| 中文摘要: |
| 目的：研究绝经女性中冠脉钙化积分(CACS)与臂踝动脉脉搏波传导速度(baPWV)之间的相关性。方法：从1918名社区人群
筛选出546 名无冠心病病史并可以进行CACS 检查的绝经女性为样本，对其进行标准化问卷调查、实验室指标检测、baPWV 及
CACS测量。根据CACS将研究对象分为CACS=0 组和CACS＞0 组，并根据baPWV 四分位数进行分组，利用logistic 回归分析
冠脉钙化与baPWV 的相关性。结果：研究人群中CACS＞0 组87 例（15.9 %），CACS=0 组459 例（84.1 %）。其中CACS＞0 组在年
龄、BMI、高血压、收缩压、总胆固醇、低密度脂蛋白及糖尿病方面均高于CACS=0组。同时，CACS＞0 组baPWV 比CACS=0 组高
（27.6%vs. 24.2 %，35.6%vs. 23.1 %），两组间差异有统计学意义（P=0.011），并且Logistic 回归发现，绝经女性年龄（OR=1.094，95
%CI 1.039-1.152，P＜0.001）、高血压（OR=1.933，95 %CI 1.092-3.422，P=0.024）、baPWV 第三分位数（OR=2.435，95 %CI
1.141-5.196，P=0.021）、baPWV 第四分位数（OR=3.323，95 %CI 1.594-6.930，P=0.001）是冠脉钙化的独立危险因素。结论：绝经女性
baPWV 升高与CACS相关，baPWV 可以作为一种评估冠脉钙化程度和心血管风险的有效手段得以应用。 |
| 英文摘要: |
| Objective:To assess the association between coronary artery calcium scoring (CACS)and brachial ankle pulse wave
velocity (baPWV)in post-menopause women.Methods:We collected a total of 546 post-menopausal women who could carry out CACS
examination and had no cardiovascular disease from 1,918 people community people as an example. And these women were underwent
examinations of questionnaire interview, anthropometric measurements, biochemical indexes, baPWV testing and CACS assessment.
According to CACS, we divided study population into two groups: CAC=0 group and CAC>0 group, and then we also divided study
population into 4 categories according to baPWV quantiles. After that，the association between baPWV and CAC was analyzed by logistic
regression.Results:There are 87 people (15.9 %)in CAC>0 group and 459 people (84.1 %)in CAC=0 group. And compared with the
CAC=0 group, the CAC>0 group had obvious higher rates in age, BMI, hypertension, systolic blood pressure, total cholesterol, low density
lipoprotein and diabetes (P<0.05). And the higher prevalence of baPWV in post-menopausal women was in CAC＞0 group (27.6 %
vs. 24.2 %, 35.6%vs. 23.1 %respectively, P=0.011). Fromlogistic regress analysis, we found age(OR=1.094, 95 %CI 1.039-1.152, P<0.
001）, hypertension(OR=1.933，95 %CI 1.092-3.422, P=0.024), baPWV 3rd quantile(OR=2.435，95 %CI 1.141-5.196, P=0.021)and baPWV
4th quantile (OR=3.323, 95 %CI 1.594-6.930, P=0.001)were independent of CAC risk factors.Conclusion:Higher baPWV was significantly
associated with the extent of CAC in post-menopausal women. baPWV can be used as an effective tool to assess the extent of
coronary artery calciumand cardiovascular risk. |
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