| 张振山 姚天宇 蒋玥 刘非 王国华.晚期肺癌化疗患者发生医院感染的病原菌分布及危险因素分析[J].,2017,17(2):345-348 |
| 晚期肺癌化疗患者发生医院感染的病原菌分布及危险因素分析 |
| Pathogenic Bacteria Distribution and Risk Factors of Nosocomial Infectionsin Advanced Lung Cancer Patients Underwent Chemotherapy |
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| DOI： |
| 中文关键词: 晚期肺癌 化疗 医院感染 病原菌 分布 危险因素 |
| 英文关键词: Advanced lung cancer Chemotherapy Nosocomial infection Pathogenic bacteria Distribution Risk factors |
| 基金项目: |
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| 中文摘要: |
| 目的：研究晚期肺癌化疗患者发生医院感染的病原菌分布及危险因素，为临床预防及降低医院感染提供参考。方法：选择从
2012 年9月-2015 年9 月在我院接受化疗治疗的晚期肺癌患者235 例进行研究。调查并统计所有患者的病历资料，对感染者的
鼻拭子、痰标本及腹水等标本进行细菌鉴定及药敏试验，分析晚期肺癌化疗患者发生医院感染的危险因素。结果：235例晚期肺癌
化疗患者中，发生医院感染65 例，感染率为27.66%，共检出病原菌75 株，其中革兰阴性菌41 株，占54.67%，革兰阳性菌26 株，
占34.67%，真菌8 株，占10.67%。肺炎克雷伯菌对氨苄西林的耐药率最高，为80.00%，对万古霉素的敏感率最高，为100.00%；金
黄色葡萄球菌对青霉素的耐药率最高，为94.74%，对利奈唑胺的敏感率最高，为100.00%。根据Logistic 回归分析法评价可知，晚
期肺癌化疗患者发生医院感染的危险因素主要有：年龄≥ 60 岁、临床分期为Ⅳ期、接受放疗、存在贫血、使用抗生素以及住院时
间≥ 15d。结论：导致晚期肺癌化疗患者发生医院感染的主要病原菌为肺炎克雷伯菌以及金黄色葡萄球菌，且年龄≥ 60 岁、临床分
期为Ⅳ期、接受放疗、存在贫血、使用抗生素以及住院时间≥ 15d 均为影响晚期肺癌化疗患者发生医院感染的危险因素，值得临床
重视。 |
| 英文摘要: |
| Objective:To study the pathogenic bacteria distribution and risk factors of nosocomial infections in advanced lung
cancer patients underwent chemotherapy,so as to provide the reference for clinical prevention and reduction of nosocomial infections.Methods:A total of 235 patients with advanced lung cancer who were underwent chemotherapy in our hospital from September 2012 to
September 2015 were selected for the research, the clinical data were investigated and analyzed,and the bacteria identification and drug
sensitivity test were carried out on nasal swab, sputumspecimen and ascites, etc. The risk factors of nosocomial infection in patients with
advanced lung cancer underwent chemotherapy were analyzed.Results:In those 235 patients, 65 patients occurred nosocomial infection,
the infection rate was 27.66%, 75 strains of pathogenic bacteria were detected, including 41 strains of gram negative bacteria, accounting
for 54.67%, 26 strains of gram positive bacteria, accounting for 34.67%, and 8 strains of fungi, accounting for 10.67%. Drug resistance
rate of Klebsiella pneumoniae to ampicillin was highest to 80.00%, and the sensitive rate to vancomycin was highest to 100.00%; Drug
resistance rate of Staphylococcus aureus to penicillin was highest to 94.74%, and the sensitive rate to linezolid was highest to 100.00%.
Logistic regression analysis showed that, the mainly risk factors of nosocomial infection in patients with advanced lung cancer underwent
chemotherapy were: age≥ 60 years old and clinical stage IV, radiotherapy, anemia, using antibiotics and hospitalization time≥ 15 days.Conclusion:The main pathogenic bacterias causing nosocomial infection in patients with advanced lung cancer underwent chemotherapy
were and , and age ≥ 60 years old and clinical stage IV, radiotherapy,anemia,using
antibiotics and hospitalization time≥ 15 days were its risk factors, which should pay attention in clinical practice. |
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