| 魏春玲,刘一辉,刘志强,任 维,师梅梅.多巴胺调节海马神经元可塑性的研究进展[J].,2017,17(1):194-197 |
| 多巴胺调节海马神经元可塑性的研究进展 |
| Advances in Modulation of Neuronal Plasticity of neuron in Hippocampus by Dopamine |
| 投稿时间：2016-03-13 修订日期：2016-03-30 |
| DOI：10.13241/j.cnki.pmb.2017.01.049 |
| 中文关键词: 多巴胺 海马 神经元可塑性 |
| 英文关键词: Dopamine Hippocampus Neuronal plasticity |
| 基金项目:国家自然科学基金项目（31040037） |
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| 摘要点击次数: 836 |
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| 中文摘要: |
| 摘要：多巴胺是脑内重要的信息传递物质，不仅可以作为递质释放到前额叶、伏隔核等脑区，直接进行信息传递，也可以作为调质调节其它突触递质的传递，并影响神经元可塑性。海马参与构成边缘系统，受多巴胺能神经支配，执行着有关学习记忆以及空间定位的功能。海马神经元的可塑性是学习记忆的细胞分子基础。研究表明，多巴胺对海马神经元的突触可塑性和兴奋性可塑性都具有重要的调节作用。本文扼要综述多巴胺对海马神经元突触可塑性和兴奋性可塑性的调节机制的研究进展，以期为DA系统参与海马区学习记忆功能的研究提供新思路，更深入地了解学习记忆的神经机制。 |
| 英文摘要: |
| ABSTRACT: Dopamine, an important chemical for information transmission in the brain, can not only transfer information directly as a neurotransmitter when released in prefrontal, nucleus accumbens and other brain areas, but also regulate other transmitters and affect neuronal plasticity as a neuromodulator. The hippocampus is included in limbic system, which is innervated by the dopaminergic system, and performs the function of learning and memory as well as spatial location. The neuronal plasticity in hippocampus is the molecular ba- sis of learning and memory. It has been shown that dopamine plays an important role in the regulation of synaptic plasticity and excitabil- ity of neurons in hippocampus. In this paper, we summarized the regulation mechanisms of synaptic plasticity and excitability of neurons in hippocampus modulated by dopamine, and provides a new way to study the role of DA system in learning and memory. |
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