| 马静雯,宋 萌,潘劲松,吴建楠,孟冉冉.牙周膜成骨分化研究进展[J].,2017,17(1):181-184 |
| 牙周膜成骨分化研究进展 |
| Research Progress of Osteogenic Differentiation of Periodontal Ligament |
| 投稿时间：2016-03-10 修订日期：2016-03-30 |
| DOI：10.13241/j.cnki.pmb.2017.01.046 |
| 中文关键词: 牙周膜 成骨分化 影响因素 MAPKs通路 |
| 英文关键词: Periodontal ligament Osteogenic differentiation Factors MAPKs pathway |
| 基金项目:国家自然科学基金项目（11172177）；上海交通大学医工理交叉基金项目（YG2010MS07） |
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| 中文摘要: |
| 摘要：牙周膜是位于牙根与牙槽骨之间的结缔组织，具有自我更新和多向分化的能力。无论是在正畸治疗还是在牙周组织修复及再生过程中，牙周膜的成骨分化都是必不可少的。近年来，许多国内外学者致力于研究影响牙周膜成骨分化的因素，包括机械力，细胞因子，药物等，这些因素可以单独作用于牙周膜，也可以联合使用加快牙周膜成骨分化，可以为临床上加快牙齿移动和修复牙周组织缺损提供更多新的思路。现就影响牙周膜成骨分化的诸多因素及其主要机制作一综述。 |
| 英文摘要: |
| ABSTRACT: The periodontal ligament is the connective tissue between the tooth root and alveolar bone and has the ability of self-renewal and multi-directional differentiation. Osteogenic differentiation of periodontal membrane is indispensable in both orthodon- tics and periodontium repair and regeneration. Recently, many scholars are dedicated to study the factors influencing osteogenic differen- tiation of periodontal ligament, such as mechanical force, cytokines and drugs, and so on. And these factors can not only be used in the periodontal ligament solely, but also be used in combination with speeding up osteogenic differentiation of periodontal ligament, which can provide more new ways for accelerating tooth movement and repairing periodontal defects. Now, we reviewed the factors that affect the osteogenic differentiation of periodontal ligament and its main mechanisms in this paper. |
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