| 朱宏伟,孙 娟,徐成伟,牛 俊,徐明义,崔晓波.芩蒿滴鼻液对变应性鼻炎患者鼻分泌物中SP, TNF-α, Annexin1及VCAM-1含量的影响[J].,2017,17(1):73-76 |
| 芩蒿滴鼻液对变应性鼻炎患者鼻分泌物中SP, TNF-α, Annexin1及VCAM-1含量的影响 |
| Effect of Scutellaria Artemisia Nasal Drops on the SP, TNF-α, Annexin1 and VCAM-1 Levels in Nasal secretions of Patients with Allergic Rhinitis |
| 投稿时间：2016-08-08 修订日期：2016-08-24 |
| DOI：10.13241/j.cnki.pmb.2017.01.018 |
| 中文关键词: 芩蒿滴鼻液 变应性鼻炎 P物质 肿瘤坏死因子-α 膜联蛋白1 血管细胞黏附分子-1 |
| 英文关键词: Qin Hao nasal drops allergic rhinitis substance P tumor necrosis factor alpha annexin 1 vascular cell adhesion molecule -1 |
| 基金项目:内蒙古科学技术委员会资助项目(20001306) |
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| 中文摘要: |
| 摘要 目的：探讨芩蒿滴鼻液对变应性鼻炎(AR)患者鼻分泌物中P物质(SP)、肿瘤坏死因子-α(TNF-α)、膜联蛋白1 (Annexin1)、血管细胞黏附分子-1(VCAM-1)含量的影响。方法：选取我院耳鼻喉科收治的AR患者92例，随机分为对照组和实验组两组。对照组46例患者予曲安奈德鼻喷雾剂治疗，实验组46例患者加用芩蒿滴鼻液治疗。另选取健康体检患者46例。采用酶联免疫法测定各组患者鼻分泌物中TNF-α、Annexin1及VCAM-1的含量，采用放射免疫法测定SP的含量。结果：治疗后，两组鼻分泌物中SP、TNF-α及VCAM-1含量均较治疗前显著下降，Annexin1含量明显升高(P＜0.05)；与对照组比较，实验组鼻分泌物中SP、TNF-α及VCAM-1含量较低(P＜0.05)，Annexin1含量较高(P＜0.05)，实验组临床有效率(91.30 %)较对照组(73.91 %)显著升高，差异具有统计学意义(P＜0.05)。结论：芩蒿滴鼻液能够明显降低AR患者鼻分泌物中SP、TNF-α、VCAM-1的含量，上调Annexin1的含量。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of Scutellaria Artemisia Nasal Drops on the SP, TNF-α, Annexin1 and VCAM-1 levels in the nasal secretions of patients with allergic rhinitis(AR). Methods: 92 cases of patients with AR were selected and randomly di- vided into two groups. 46 cases in the control group were treated with triamcinolone acetonide spraying agent 20ug/kg, three times a day,sprayed into the nose, 46 cases in the experimental group were treated with Qin Hao nasal drops three times a day 2 weeks for a course of treatment, the TNF- alpha, Annexin1 and VCAM-1 in nasal secretions were determined by ELISA, SP content of inflammatory mediators was determined by radioimmunoassay. Results: After the treatment, the content of SP, TNF- alpha and VCAM-1 were decreased, the An- nexin1 was increased. Compared with the control group, the SP, TNF- alpha and VCAM-1 levels as well as the clinical efficacy of ex- perimental group were lower(P＜0.05), the content of Annexin1 of experiment was higher(P＜0.05). Conclusion: Qin Hao nasal drops could significantly reduce the SP, TNF- alpha, VCAM-1 content and upregulate the Annexin1 content in the nasal secretions of AR pa- tients. |
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