| 王蕾 杜仕静 朱迪娜 吕翠 张文生.甲基乙二醛在阿尔茨海默病中的作用[J].,2015,15(35):6994-6996 |
| 甲基乙二醛在阿尔茨海默病中的作用 |
| The Role of Methylglyoxal in Alzheimer's Disease |
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| DOI： |
| 中文关键词: 甲基乙二醛 阿尔茨海默病 beta-淀粉样蛋白 tau蛋白 活性氧 |
| 英文关键词: Methylglyoxal Alzheimer's disease beta-amyloid peptide Tau protein Reactive oxygen species |
| 基金项目:国家自然科学基金项目（81274118; 81230010） |
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| 中文摘要: |
| 糖酵解毒性副产物甲基乙二醛（methylglyoxal，MG）以其高反应活性在阿尔茨海默病（Alzheimer's disease，AD）发生发展过
程中起到了重要的作用。MG 在AD病人脑中累积并促进beta淀粉样蛋白(beta-amyloid peptide，A beta)的产生和寡聚。大量累积的MG 通
过形成晚期糖基化终末产物(advanced glycosylation end products，AGEs)加剧了神经元中tau 蛋白的过度磷酸化。研究还发现MG
和AGEs 均参与了AD 脑中活性氧（reactive oxygen species，ROS）的产生和炎症的发生发展。本文总结了MG 在AD 病理过程中
的作用，并加以综述。 |
| 英文摘要: |
| Methylglyoxal (MG), a toxic by-product of glycolysis, plays an important role in the process of Alzheimer's disease
(AD) with its high reactivity. Accumulated MG in AD patients' brains promotes beta-amyloid peptide (A-beta) production and oligomerization.
Accumulated methylglyoxal induces tau hyperphosphorylation via Promoting advanced glycosylation end products (AGEs) Formation.
Previous studies found that MG and AGEs are both involved in the production of reactive oxygen species (ROS) and the development of
inflammation in AD patients' brains. In this article, we brief summarize and review the role of MG in pathological process of AD. |
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