| 陈建华 张乐蒙 周辉 徐建华 文晓萍 周文伟 易辉煌.482 例非小细胞肺癌远处转移临床特征的回顾性分析[J].,2015,15(35):6900-6903 |
| 482 例非小细胞肺癌远处转移临床特征的回顾性分析 |
| Metastasis Features of 482 Patients with Stage IV Non-small Cell LungCancer and Retrospective Analysis of its Relationship with ClinicopathologicFactors |
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| DOI： |
| 中文关键词: 非小细胞肺癌 临床特征 远处转移 回顾性分析 |
| 英文关键词: Non-small cell lung cancer (NSCLC) Clinical characters Distant metastasis Retrospective analysis |
| 基金项目:湖南省卫生厅科研基金项目（B2011-090） |
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| 中文摘要: |
| 目的：探讨不同病理类型IV 期非小细胞肺癌(NSCLC)患者远处转移的临床特征。方法：回顾性分析我科收治的482 例诊断
明确IV 期NSCLC 患者的临床资料，比较不同病理类型患者各器官远处转移发生率，并进行统计学分析。结果：482 例IV 期
NSCLC 患者中，鳞状细胞癌188 例(39.0%)，腺癌275 例(57.1%)，大细胞癌5 例(1.0%)，腺鳞癌14 例(2.9%)。平均年龄55.2 岁，男
女比例为2.30：1，高发年龄为40～60 岁。各器官远处转移的发生率从高到低依次为：骨217 例(45.0%)，胸膜170 例(35.3%)，双肺
138例(28.6%)，脑113 例(23.4%)，肝85 例(17.6%)，肾上腺33 例(6.8%)，心包36 例(7.5%)。单器官转移221 例(45.9%)，多器官转移
261例(54.1%)。T4 期患者所占比例高达44.8%，N2+3 组患者所占比例明显高于N0+1 组患者，差异有统计学意义。单纯骨、脑、肝、
肾上腺转移发生率分别为28.1%、23.9%、12.9%和15.2%。结论：NSCLC 以骨和胸膜转移最为常见，原发肿瘤情况、淋巴结转移情
况与远处转移存在一定关系，多数M1b 期患者初诊时已发生全身多部位远处转移。 |
| 英文摘要: |
| Objective:To investigate the characteristics and regularity of the distant metastasis of stage IV non-small cell lung cancer
(NSCLC) with different pathological types.Methods:A total of 482 patients with stage IV NSCLC, with complete clinical and pathological
data, were investigated retrospectively. The distant metastasis rates of different pathological types of lung cancer were analyzed
and compared statistically.Results:Among the 482 cases of stage IV NSCLC, 188 cases had squamous cell carcinoma (39%), 275 cases
had adenocarcinoma (57.1%), 5 cases had large cell carcinoma (1%), and 14 cases had adenosquamous carcinoma (2.9%). The average
age was 55.2 years old, the male to female ratio was 2.30∶1 and 40 to 60 years old was the age vulnerable to NSCLC. The incidence of
distant metastases was: bone metastases in 217 cases (45%), pleural metastases in 170 cases (35.3%), double lung metastases in 138 cases
(28.6%), brain metastases in 113 cases (23.4%), liver metastases in 85 cases (17.6%), adrenal metastases in 33 cases (6.8%), pericardium
metastases in 36 cases (7.5%). There were 221 cases with single organ metastasis (45.9%) and 261 with multiple organ metastasis
(54.1%). The proportion of patients in stage T4 was as high as 44.8%, and the proportion of patients in stage N2+3 was significantly higher
than that of patients in the N0+1 group. Single metastasis rate of bone, brain, liver and adrenal was only 28.1%, 23.9%, 12.9% and
15.2%respectively.Conclusion:Bone and pleural metastasis were the most common distant metastasis for NSCLC patients. There was a
relationship between primary tumor, lymph node metastasis and distant metastasis. The majority of newly diagnosed patients with M1b
stage have distant metastasis in multiple different organs. |
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