| 鲁景元 徐文健 汪涛 楼文胜 顾建平.外周动脉疾病治疗进展[J].,2016,16(33):6593-6660 |
| 外周动脉疾病治疗进展 |
| Advances in the Treatment of Peripheral Arterial Disease |
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| DOI： |
| 中文关键词: 外周动脉疾病 细胞治疗 腔内治疗 药物涂层球囊 |
| 英文关键词: Peripheral arterial disease Cell therapy Intracavitary therapy Drug eluting Balloon |
| 基金项目:国家自然科学基金项目（81541061）；江苏省科技发展基金临床医学专项(BL2014013)；
南京市卫生科技发展基金重点项目(ZKX10004)；南京市科技发展项目(201402049) |
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| 中文摘要: |
| 外周动脉疾病（PAD）与心血管疾病（CV）的发病率和死亡率有着密切的联系。ACCF/AHA指南建议无症状和症状性PAD
患者戒烟并应用抗血小板/抗凝药物。对于存在严重肢体缺血（CLI）的PAD 患者应考虑接受腔内与开放保肢手术治疗。即便存在
CLI的PAD患者接受如上治疗，有时仍无法为患肢提供足够的血流灌注以消除症状。为建立有效血供，许多研究已经深入细胞治
疗层面。内皮干细胞、单核细胞和骨髓间充质干细胞在临床应用中得到了很好的研究。血管内皮生长因子、成纤维细胞生长因子
和肝细胞生长因子（HGF）也被应用于PAD 患者，以诱导血管生成。其中，HGF最有优势，因为它可诱导血管生成却不伴有反应性
血管炎及血管通透性增高。同时，血管腔内治疗器械及技术，如药物涂层球囊等也获得较快发展。本文将PAD治疗进展综述如下。 |
| 英文摘要: |
| Peripheral artery disease (PAD) is associated with elevated morbidity and mortality with cardiovascular (CV) disease.
The guideline recommends smoking cessation and antiplatelet/antithrombotic drugs for asymptomatic and symptomatic PAD patients.It
also recommends that PAD patients with critical limb ischemia (CLI) should be considered to receive endovascular and open surgical
treatment for limb salvage. Although PAD patients with CLI receive these treatments, they are sometimes unable to deliver sufficient
blood flow to eliminate their symptoms. Thus specific strategies are needed to promote enough blood flow.To establish the effective
method, many investigations have been performed using cell-based therapy. Endothelial progenitor cells, mononuclear cells and
mesenchymal stem cells have been well investigated in clinical settings. To induce angiogenesis, vascular endothelial growth factor,
fibroblast growth factor and hepatocyte growth factor (HGF) have also been transfected in PAD patients. Among them, HGF is the most
promising factor because it can induce angiogenesis without the induction of vascular inflammation and increased permeability. At the
same time, endovascular treatment equipment and technology, such as drug eluting balloon, also obtained rapid development. In this
review article, the current progress in the treatment of PAD was summarized. |
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