| 沈丽莎 李锦伟 黄珊 季黎明 石勇铨.RAAS及血清TGF-β1水平对糖尿病肾病伴高血压患者肾功能损伤的影响[J].,2016,16(32):6360-6363 |
| RAAS及血清TGF-β1水平对糖尿病肾病伴高血压患者肾功能损伤的影响 |
| Effect of RAAS and Serum TGF-β1 Level on Renal Function Injury inDiabetic Nephropathy Patients with Hypertension |
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| DOI： |
| 中文关键词: RAAS TGF-β1 糖尿病肾病 高血压 肾功能 |
| 英文关键词: Renin angiotensin aldosterone system Transforming growth factor-β Diabetic nephropathy Hypertension Renal
function |
| 基金项目:2014 年度上海市同仁医院院级科研基金项目（TR201410） |
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| 中文摘要: |
| 目的：探究肾素-血管紧张素- 醛固酮系统(RAAS)与转化生长因子-β1(TGF-β1)对糖尿病肾病(DN)合并高血压患者肾功能
损伤的影响，为临床治疗提供依据。方法：选择2014年6 月2015 年6月期间我院收治的DN 患者76 例为研究对象, 根据是否合
并高血压将其分为DN 合并高血压组（39 例）和单纯DN组（37 例）,另选择我院健康体检者40 例为对照组，检测并比较各组间醛
固酮(ALD)、肾素、血管紧张素(ATII )、血肌酐(Scr) 、肾小球率过滤估计值（eGFR）、尿素氮(BUN)及尿N-乙酰-β-D 氨基葡萄糖苷
酶( NAG)水平。结果：DN合并高血压组与单纯DN 组患者肾素、ATII、Scr、BUN、TGF-β1 及NAG 水平显著高于对照组，DN 合并
高血压组肾素、ATII、Scr、BUN及TGF-β1 水平均显著高于单纯DN组，差异均具有统计学意（P<0.05）；DN 合并高血压组患者
eGFR 水平显著低于对照组与单纯DN 组，且单纯DN组显著低于于对照组，差异均具有统计学意（P<0.05）；Wilcoxon 秩和检验
显示，DN 合并高血压组肾素、ATII、Scr、BUN、TGF-β1 及NAG 水平随DN 分级增加而增加，eGFR 水平随DN 分级的增加而降
低，差异均有统计学意义（P<0.05）；DN 合并高血压组患者肾素、ATII 及TGF-β1 水平与eGFR 水平呈现负相关关系（r=-0.523,-0.
601,-0.401;P<0.05）, 与Scr（r=0.338, 0.414,0.141,P<0.05）及NAG（r=0.341, 0.413, 0.411; P<0.05）呈现正相关关系。结论：DN伴高血
压患者机体RAAS及血清TGF-β1 水平均显著升高，且患者DN 病情越重，其水平越高。 |
| 英文摘要: |
| Objective:To study the effect of renin angiotensin aldosterone system (RAAS)and serum transforming growth
factor-β1 (TGF-β1)level on renal injury function in diabetic nephropathy (DN) patients with hypertension, so as to provide basis for
clinical treatment.Methods:Selected 76 cases of patients with DN who were treated in our hospital from June 2014 to June 2015 as the
objects,and were divided into DN with hypertension group (n=39) and simple DN group (n=37) according to whether or not combined
with hypertension, than selected 40 cases of healthy physical examination people in our hospita as the control groupl, detected and
compared the levels of aldosterone (ALD), renin, angiotensin (ATII), serumcreatinine (Scr), estimated glomerular filtration rate(eGFR),
urea nitrogen(BUN) and N-acetyl-β-D-glucosaminidase(NAG).Results:The levels of renin, ATII, Scr, BUN, TGF-茁1 and NAG in DN
with hypertension group and simple DN group were higher than that of control group, the levels of renin, ATII, Scr, BUN, TGF-茁1 and
NAG in DN with hypertension group were higher than that of simple DN group, the differences were statistically significant(P<0.05); The
levels of eGFR in DN with hypertension group was lower than the control group and simple DN group, and the simple DN group was
lower than that of the control group, the differences were statistically significant (P<0.05); Wilcoxon rank sumtest showed that the levels
of renin, ATII, Scr, BUN, TGF-β1 and NAG in DN with hypertension group were increased alone with the increase of DN grade, the
level of eGFR was decreased alone with the increase of DN grade, the differences were statistically significant (P<0.05); The levels of
renin, ATII and TGF-β1 were negatively correlated with the level of eGFR of patients in DN with hypertension in group (r=-0.523, -0.
601, -0.401; P<0.05), and were positively correlated in Scr (r=0.338, 0.414, 0.141, P<0.05) and NAG (r=0.341, 0.413, 0.411; P<0.05).Conclusion:The levels of RAAS and TGF-β1 are highly in DN patients with hypertension, and the sever of the DN of patients, the higher of the level. |
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