| 陈文慧 唐亚平 周欣 刘乐 曹家琪 李百灵 李伯埙.钙泊三醇倍他米松软膏联合NB-UVB对掌跖脓疱病患者
血清TNF-alpha, IL-17水平的影响[J].,2016,16(32):6342-6344 |
| 钙泊三醇倍他米松软膏联合NB-UVB对掌跖脓疱病患者
血清TNF-alpha, IL-17水平的影响 |
| Effect of Calcipotriol Betamethasone Ointement plus NB-UVB on theTNF-alpha, IL-17 Levels in Serumof Patients with Palmoplantar Pustulosis |
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| DOI： |
| 中文关键词: 钙泊三醇倍他米松 窄谱中波紫外线 掌跖脓疱病 肿瘤坏死因子-alpha 白细胞介素-17 |
| 英文关键词: Calcipotriol betamethasone NB-UVB Palmoplantar pustulosis TNF-alpha IL-17 |
| 基金项目:广东省科技计划项目-社会发展项目（2012A030400050） |
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| 中文摘要: |
| 目的：观察钙泊三醇倍他米松软膏联合窄谱中波紫外线(NB-UVB)治疗掌跖脓疱病的临床疗效及对患者血清肿瘤坏死因子
-alpha(TNF-alpha)、白细胞介素-17(IL-17)水平的影响。方法：选取掌跖脓疱病患者63 例，随机分为治疗组和对照组，治疗组外用钙泊三醇
倍他米松软膏联合NB-UVB 治疗，对照组单纯照射NB-UVB，两组患者的疗程均为8 周，治疗4 周及8 周后观察临床疗效，并测
定血清中TNF-琢、IL-17 的浓度。结果：治疗4周和8 周后，治疗组症状积分较对照组明显下降，差异有统计学意义(P<0.05)；治疗4
和8 周时，对照组的有效率分别为22.58 %和45.16 %，治疗组为53.13 %和78.13 %，两组患者的有效率比较差异显著(P<0.05)；停
药后3 个月，对照组复发率为35.48 %，治疗组复发率为12.50 %，治疗组明显低于对照组；治疗后两组患者血清中TNF-alpha、IL-17
的浓度均较前下降，且治疗组较对照组下降更明显，差异具有统计学意义(P<0.05)。结论：钙泊三醇倍他米松软膏辅助治疗可以更
有效提高掌跖脓疱病患者的临床疗效，且安全性较好，这可能与其降低患者外周血中TNF-琢和IL-17 的水平有关。 |
| 英文摘要: |
| Objective:To observe the efficiency of calcipotriol betamethasone ointement combined with NB-UVB in the treatment
of palmoplantar pustulosis and influence on TNF-alpha、IL-17 levels in serum.Methods:63 patients with palmoplantar pustulosis were
randomly divided into two groups, the patients of both groups were treated with NB-UVB, once every two days. At the same time,
patients in the treatment group were treated by calcipotriol betamethasone ointement. The duration of treatment was 8 weeks, and the
efficacy was observed at the fourth and eighth weekend, the concentrations of TNF-alpha, IL-17 were measured in serum.Results:At 4 and 8
weeks after treatment, the clinical symptom score of treatment group declined more dramatically than that of the control group (P<0.05);
At the fourth and eighth weekend, the efficiency of control group were 22.58%and 45.16%respectively, which were 53.13%and 78.13
%respectively in the treatment group (P<0.05). At 3 months after drug discontinuance, the recurrence rate of control group was 35.48 %,
which was 12.50%in the treatment group and significantly lower than that of the control group (P<0.05). The concentrations of TNF-alpha,
IL-17 in serum of both groups were declined, which declined more obviously in the treatment group than that of the control group (P<0.
05).Conclusion:The adjuvant therapy of calcipotriol betamethasone ointement could more effectively improve the clinical efficacy of
palmoplantar pustulosis, the safety was higher, which might be correlated with the decline of serumTNF-alpha, IL-17 concentrations. |
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