| 靳瑾 罗荔 李晓岚 薛以贵 王思遥.短期胰岛素泵强化治疗对2 型糖尿病患者脂糖代谢及胰岛β细胞功能的影响[J].,2016,16(32):6313-6315 |
| 短期胰岛素泵强化治疗对2 型糖尿病患者脂糖代谢及胰岛β细胞功能的影响 |
| Effect of Intensive Treatment of Short-term Insulin Pump on GlycolipidMetabolismand Islet β-cell Function for the Patients with Type 2 Diabetic Mellitus |
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| DOI： |
| 中文关键词: 2型糖尿病 胰岛素泵 糖脂代谢 胰岛β细胞 |
| 英文关键词: Type 2 diabetic mellitus Insulin pump Glycolipid metabolism Islet β-cells |
| 基金项目:新疆医科大学科研创新基金项目（XJC2012133） |
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| 中文摘要: |
| 目的：探讨短期胰岛素泵强化治疗对2 型糖尿病患者脂糖代谢及胰岛β细胞功能的影响。方法：选择2013 年10 月到2015
年10 月我院收治的2 型糖尿病患者86例，随机分为对照组（n=43）和实验组（n=43）。对照组患者给予门冬胰岛素常规治疗，实验
组患者给予胰岛素泵强化治疗，两组疗程均为2 周。检测并比较两组患者治疗前后血糖、血脂、糖化血红蛋白（HbA1c）及口服葡萄
糖刺激后胰岛β细胞功能指标。结果：治疗后两组患者空腹血糖（FPG）、HbA1c、总胆固醇（TC）、甘油三酯（TG）及低密度脂蛋白胆
固醇（LDL-C）、稳态模型评价- 胰岛素抵抗（HOMA-IR）较治疗前均明显下降（P<0.05），高密度脂蛋白胆固醇（HDL-C）、胰岛素曲
线下面积（AUC）、稳态模型评价- 胰岛茁细胞功能（HOMA-β）及0.5h胰岛素浓度/ 血糖浓度（I30/G30）较治疗前明显升高（P<0.
05），且实验组患者以上各指标变化均优于对照组（P<0.05）。结论：短期胰岛素泵强化治疗能明显纠正2 型糖尿病患者血糖、血脂
水平，改善胰岛茁细胞功能，值得在临床上推广应用。 |
| 英文摘要: |
| Objective:To study the effect of intensive treatment of short-term insulin pump on glycolipid metabolism and islet
β-cell function for the patients with type 2 diabetic mellitus.Methods:A total of 86 patients with type 2 diabetic mellitus in our hospital
fromOctober 2013 to October 2015 were enrolled, they were divided into control group (n=43) and experiment group (n=43) randomly.
The control group were treated with insulin aspart conventional therapy, while the experiment group were treated with intensive treatment
of short-term insulin pump, the course of treatment was 2 weeks in two groups. The plasma glucose, blood lipid, glycosylated
hemoglobin (HbA1c) and the indexes of islet β-cell function after oral glucose stimulation were detected and compared in two groups
before and after treatment.Results:After treatment, the levels of fasting plasma glucose(FPG), HbA1c, total cholesterol(TC), triglyceride
(TG), low density lipoprotein cholesterol(LDL-C)and Homeostasis model assessment-IR(HOMA-IR)in two groups significantly cut down
than before treatment (P<0.05), but the high density lipoprotein cholesterol (HDL-C), insulin area under the curv (AUC), homeostasis
model assessment-β(HOMA-β)and insulin concentration/blood glucose concentration at 0.5 h (I30/G30)in two groups significantly
increased than before treatment (P<0.05),furthermore, above indexes in experiment group changed significantly better than control group
(P<0.05).Conclusion:The intensive treatment of short-term insulin pump can obviously correct the levels of plasma glucose, blood lipid
and improve the islet β-cells function for the patients with type 2 diabetic mellitus, which is worthy application in clinic. |
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