| 王文娟 吴海波△ 杨琴 高敏 刘洋.PCOS患者外周血白细胞计数变化的临床意义[J].,2016,16(31):6118-6120 |
| PCOS患者外周血白细胞计数变化的临床意义 |
| Clinical Significance of Changes of Peripheral Leukocytes Count in Patientswith PCOS |
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| DOI： |
| 中文关键词: 多囊卵巢综合征 白细胞 血脂 炎症 |
| 英文关键词: Polycystic ovary syndrome Leukocytosis Blood lipid Inflammation |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨多囊卵巢综合征（PCOS）患者外周血白细胞计数和血脂代谢变化的临床意义。方法：随机抽取2012 年1 月~2014
年1 月期间来院就诊未经药物治疗的PCOS 患者48 例作为研究对象，将体重指数（BMI）≥ 23 的患者26 例作为PCOS 超重组，
将BMI＜23 的22例患者作为PCOS体重正常组，选择同期来院就诊的非PCOS妇女20 例作为对照组，所有患者均于月经期空
腹静脉抽血3~4mL，检测患者的血浆C 反应蛋白（CRP）、血常规及血脂代谢指标。结果：PCOS 超重组的甘油三酯（TG）、低密度脂
蛋白（LDL-C）、载脂蛋白B（Apo-B）、外周白细胞总数、淋巴细胞、中性粒细胞、单核细胞、嗜酸性细胞、CRP 指标均较对照组、
PCOS体重正常组高，而高密度脂蛋白（HDL-C）、载脂蛋白A（Apo-A）水平较对照组、PCOS 体重正常组低，差异均有统计学意义
（P<0.05）；PCOS体重正常组淋巴细胞、CRP 指标较对照组高，差异均有统计学意义（P<0.05）。结论：慢性炎症是PCOS 的主要病
理表现，其中体重超重的PCOS 患者主要表现为血脂代谢异常及白细胞升高，而体重正常的PCOS患者主要表现为淋巴细胞升
高。 |
| 英文摘要: |
| Objective:To explore the clinical significance of changes of lipid metabolism and peripheral leukocytes count in patients
with polycystic ovary syndrome (PCOS).Methods:48 PCOS patients who were treated in our hospital without drug treatment from
Feb 2013 to Feb 2014 were randomly chosen and divided into overweight PCOS group (n=26, BMI≥ 23) and normal weight PCOS
group (n=22, BMI<23). 20 cases without PCOS in the same period were selected as control group. 3~4 mL fasting venous blood were
exsanguinated from all patients in the menstrual period. Plasma C-reactive protein (CRP), blood routine and blood lipid metabolism indexes
were detected.Results:Compared with control group and normal weight PCOS group, the levels of triglyceride (TG), low density
lipoprotein (LDL-C), apolipoprotein B (Apo-B), the total number of peripheral leukocytes, lymphocytes, neutrophils, monocytes,
eosinophils and CRP in overweight PCOS group were higher, while the levels of high density lipoprotein (HDL-C) and apolipoprotein A
(Apo-A) were lower, and the differences were statistically significant (P<0.05). The levels of lymphocytes and CRP in normal weight
PCOS group were higher than the control group, and the differences were statistically significant (P<0.05).Conclusion:Chronic inflammation
is the main pathological manifestations of PCOS, among which the overweight patients with abnormal lipid metabolism and increasing
leukocytosis, while the normal-weight patients with increasing lymphocytes. |
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