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目的：研究连续血液净化治疗烧伤脓毒症的临床疗效及安全性。方法：选取我院收治的烧伤脓毒症患者110 例，随机分成观察组（n=50）和对照组（n=60）。对照组采取常规治疗，观察组采取持续性血液净化治疗。观察并比较两组患者治疗前后PaO2, WBC, GLU, Na, BUN, Cr, TNF-琢及IL-8 水平变化、临床疗效及安全性。结果：与治疗前相比，观察组患者治疗后PaO2,WBC, GLU, Na, BUN，Cr, TNF-琢及IL-8 水平均改善，且优于对照组，差异具有统计学意义（P<0.05）。观察组呼吸机使用时间和ICU住院时间均短于对照组，差异具有统计学意义（P<0.05）。观察组28 d内死亡率（12.00%）低于对照组（40.00%），差异具有统计学意义（P<0.05）。结论：持续性血液净化治疗是烧伤脓毒症治疗的安全有效方式，可改善患者各项指标，缩短呼吸机使用以及住院时间，降低患者短时间内病死率，十分具有临床价值。

英文摘要:

Objective:To study the clinical effects and safety of continuous blood purification in the treatment of burned sepsis.Methods:Select 110 patients with burned sepsis in our hospital as the research object, who were divided into observation group (n = 50) and the control group (n = 60) randomly. The control group was given conventional therapy, while the observation group received continuous blood purification treatment, on the basis of conventional therapy. Compare the clinical efficacy and safety of two groups.Results:After treatment, the level of PaO2, WBC, GLU, Na, BUN, Cr, TNF- alpha, IL-8 water in the observation group improved obviously, and that were better than that in the control group, the difference was statistically significant (P<0.05). The ventilation time, ICU length of stay of patients in the observation group were shorter than that in the control group, the difference was statistically significant (P<0.05). The 28 d mortality of observation group (12%) was improved than control group (40%), the difference had statistically significance (P<0.05).Conclusion:Continuous blood purification therapy is a safe and effective method in treating burned sepsis and can improve the indexes of patients, shorten mechanical ventilation and hospitalization time, reduce patients’fatality rate within a short period, which is of clinical value.

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