| 孙瑞 蔡迎彬 李丹萍 张琪琪 王硕 侯慧.超声内镜引导下细针穿刺活检联合基因检测对胰腺癌的诊断价值[J].,2016,16(30):5921-5922 |
| 超声内镜引导下细针穿刺活检联合基因检测对胰腺癌的诊断价值 |
| Diagnostic Value of Endoscopic Ultrasonography Guided Fine NeedleAspiration Biopsy Combined with Gene Detection for Pancreatic Cancer |
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| DOI： |
| 中文关键词: 超声内镜 细针穿刺活检 K-ras 胰腺癌 诊断 |
| 英文关键词: Endoscopic ultrasonography Fine needle aspiration biopsy K-ras Pancreatic cancer Diagnosis |
| 基金项目:2015 年新疆自治区卫生计生委青年科技人才专项科研项目（2015Y27） |
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| 中文摘要: |
| 目的：研究超声内镜引导下细针穿刺活检（EUS-FNA）联合K-ras 基因检测对胰腺癌的诊断价值，为临床诊疗提供依据。方
法：选取2013 年11 月到2015 年11月我院收治的胰腺占位病变患者90 例，患者入院次日行EUS-FNA，检测患者血清及活检物
中K-ras基因阳性率，比较EUS-FNA 单独与EUS-FNA联合K-ras 基因检测对胰腺癌诊断的准确率与敏感性。结果：90 例胰腺占
位病变者中，经病理证实胰腺癌56 例，EUS-FNA 单独与EUS-FNA联合K-ras 基因分别检出胰腺癌50 例、53 例，准确率分别为
89.29%、94.64%，敏感性分别为92.59%、98.15%，两组比较差异均有统计学意义（P<0.05）。胰腺癌患者活检物中K-ras 阳性率为
83.93%，明显高于血清中的41.07%（P<0.05）。结论：EUS-FNA联合K-ras基因检测可提高对胰腺癌诊断的准确率与敏感性。 |
| 英文摘要: |
| Objective:To study the diagnostic value of endoscopic ultrasonography guided fine needle aspiration biopsy
(EUS-FNA)combined with K-ras gene detection for pancreatic cancer, so as to provide basis for clinical diagnosis and treatment.Methods:90 cases of patients with pancreatic occupying lesions were selected treated in our hospital from November 2013 to November
2015, who were underwent EUS-FNA the next day after admission, then detected the positive rates of K-ras gene in serum and biopsy,
and compared the accuracy rate and sensitivity between EUS-FNA and EUS-FNA combined with K-ras gene detection on the diagnosis
of pancreatic cancer.Results:56 patients were confirmed with pancreatic cancer by pathology detection among 90 patients with
pancreatic occupying lesions, EUS-FNA and EUS-FNA combined with K-ras gene detection found 50 cases and 53 cases respectively,
and the accuracy rate were 89.29%vs 94.64%, sensitivity were 92.59% vs 98.15%, the differences were statistically significant(P<0.05).
The positive rate of K-ras in biopsy was 83.93%, which was significantly higher than 41.07%in serum of patients with pancreatic cancer
(P<0.05).Conclusion:EUS-FNA combined K-ras gene detection could increase the accuracy rate and sensitivity for the diagnosis of
pancreatic cancer. |
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