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目的：探讨ER琢-29 位基因多态性与HBV相关原发性肝癌（PHC）易感性的关系。方法：通过聚合酶链反应-限制性片段长度多态性法检测我院100 例HBV 相关原发性肝癌患者（PHC 组）与95 例同期健康体检者（对照组）的ERα-29 位基因多态性并对两组间各等位基因、基因型频率进行比较。结果：PHC组ERα-29 位基因的TT、TC 和CC 基因型分别有31 例(31.00%)、45 例 (45.00%)和24 例(24.00%)，T 与C 等位基因频率分别为53.50%和46.50%，对照组ERα-29 位基因的TT、TC和CC型基因型分别有11 例(11.58%)、39 例(41.05%)和45 例(47.37%)，T 与C 等位基因频率分别为32.11%和67.89%，两组间基因型分布、等位基因频率差异均具有统计学意义（P<0.05）；T等位基因发生PHC 的风险是C 等位基因的2. 43 倍( OR =2.43，95%CI: 1.37～4.32) 。结论：ERα-29 位基因与HBV 相关原发性肝癌易感性有关，其中T 等位基因可增加发生风险。

英文摘要:

Objective:To explore the relationship between ERα-29 gene polymorphisms and HBV -related hepatocellular carcinoma.Methods:polymerase chain reaction-restriction fragment length polymorphism was conducted to detect the ERα-29 gene polymorphisms of 100 HBV-related hepatocellular carcinoma patients and 95 healthy people. The alleles and genotypes between these two groups were compared.Results:The numbers of TT, TC and CC genotype of ERα-29 gene in the PHC group were 31 cases (31.00%)、45 cases(45.00%)and 24 cases(24.00%), while the rate of T and C allele were 53.50%and 46.50%respectively. The numbers of TT,TC and CC genotype of ERα-29 gene in the control group were 11 cases(11.58%),39 cases(41.05%)and 45cases(47.37%), while the rate of T and C allele were 32.11% and 67.89% respectively.The rate of genotypes and alleles between these two groups all had statistical difference(P<0.05). Compared to the C allele,the incidence of PHC of T allele carrier was 2.43 times higher(OR=2.43, 95%CI: 1.37~4.32).Conclusion:ERα-29 has a relationship with HBV-related hepatocellular carcinoma,and the T allele carrier can increase the risk.

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