| 王晶 敖传西 黄婉秋 王成 陈永华.玻璃酸钠注射液联合中药熏蒸治疗膝关节骨性关节炎的临床效果及
对患者血清TNF-α水平的影响[J].,2016,16(29):5673-5676 |
| 玻璃酸钠注射液联合中药熏蒸治疗膝关节骨性关节炎的临床效果及
对患者血清TNF-α水平的影响 |
| Effect of SodiumHyaluronate Injection Combined with Traditional ChineseMedicine Fumigation on Serum Levels of TNF-αof Patients with KneeOsteoarthritis |
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| DOI： |
| 中文关键词: 玻璃酸钠 中药熏蒸 膝关节骨性关节炎 TNF-α IL-1β |
| 英文关键词: Sodiumhyaluronate Chinese medicine fumigation Knee osteoarthritis TNF-α IL-1β |
| 基金项目:湖北省自然科学基金项目(2013CFC035) |
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| 中文摘要: |
| 目的：探讨玻璃酸钠注射液联合中药熏蒸对膝关节骨性关节炎患者血清TNF-α水平的影响及其临床疗效。方法：选取我院
膝关节骨性关节炎患者70 例，随机分为实验组和对照组，每组35 例。对照组给予玻璃酸钠注射液；实验组在对照组治疗基础上
联合中药熏蒸治疗。比较治疗前后两组患者血清TNF-α、IL-1β水平及临床疗效。结果：实验组总有效率(88.57%) 高于对照组
(71.43%)，差异具有统计学意义(P＜0.05)。与治疗前相比，两组患者治疗后血清TNF-α、IL-1β水平均降低，且实验组低于对照组，
差异具有统计学意义(P＜0.05)；与治疗前相比，两组患者治疗后膝关节功能评分、ROM 均升高，而VAS 评分均降低，差异具有统
计学意义(P＜0.05)；与对照组比较，实验组患者治疗后膝关节功能评分、ROM较高，而VAS 评分较低，差异具有统计学意义(P＜
0.05)。结论：玻璃酸钠注射液联合中药熏蒸对膝关节骨性关节炎患者有较好的临床疗效，推测其机制与TNF-α、IL-1β水平降低有
关。 |
| 英文摘要: |
| Objective:To investigate the effect of sodium hyaluronate injection combined with traditional Chinese medicine fumigation
on serum levels of TNF-αand clinical effect in patients with osteoarthritis.Methods:70 cases with knee osteoarthritis who were
treated in our hospital were selected and randomly divided into the experimental group and the control group, with 35 cases in each
group. The patients in the control group were treated with sodium hyaluronate injection, while the patients in the experimental group
were treated with traditional Chinese medicine fumigation combined with sodium hyaluronate injection. Then the serum levels of TNF-α
and IL-1βand the clinical effect in the two groups were observed and compared before and after the treatment.Results:The clinical efficacy
of the experimental group was 88.57%, which was higher than 71.43% of the control group, and the difference was sta- tistically
significant (P<0.05); Compared with before treatment, the serumlevels of TNF-αand IL-1βin the two groups decreased, and the experimental
group were lower than those of the control group, and the differences were statistically significant (P<0.05); Compared with before
treatment, the lysholmand ROMin the two groups increased, while the VAS decreased, and the differences were statistically significant
(P<0.05); Compared with the control group after treatment, the lysholm and ROMin the experimental group were higher, while the
VAS was lower, and the differences were statistically significant (P<0.05).Conclusion:Sodium hyaluronate injection combined with traditional
Chinese medicine fumigation has good clinical efficacy in the treatment of knee osteoarthritis, that might be relative to the reduction
of TNF-αand IL-1βlevels. |
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